Product apis-epigentics

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Catalog	name	Description	price
R-C-1315	RG2833 (RGFP109) CAS:1215493-56-3	RG2833 is a brain-penetrant HDAC inhibitor with IC50s of 60 nM and 50 nM for HDAC1 and HDAC3,respectively.The Ki values for HDAC1 and HDAC3 are 32 and 5 nM, respectively.	price>
R-C-1335	XY1 CAS：1624117-53-8	XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM.SGC707 is a potent,selective allosteric inhibitor of PRMT3(IC50=50nM).It inhibits the methylation of histones in cells with an IC50 value below 1 µM.	price>
R-C-1360	GSKJ4HCL CAS No. 1797983-09-5	GSK-J4 is a cell permeable,potent and selective histone demethylase.GSK-J4 is a prodrug of GSK J1,which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.GSK-J4 is used to probe the consequences of demethylation of H3K27me3.GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines,including pro-inflammatory tumour necrosis facto(TNF).	price>
R-C-1368	PFI-4 CAS：900305-37-5	PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50=80nM).Exhibits>100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2(BRD1),BRPF3 and BRD4.	price>
R-C-1379	CUDC-101 CAS:1012054-59-9	CUDC-101 is a multi-targeted,small-molecule inhibitor of histone deacetylase (HDAC),epidermal growth factor receptor tyrosine kinase(EGFR/ErbB1),and human epidermal growth factor receptor 2 tyrosine kinase(HER2/neu or ErbB2)with potential antineoplastic activity.HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown.This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous,synergistic inhibition of EGFR,Her2,and HDAC.	price>
R-C-1435	LLY-507 CAS：1793053-37-8	LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2,LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50<15 nM.LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.	price>
R-C-1436	HLCL-61 HCL CAS：1158279-20-9	HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia.HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML(acute myeloid leukemia)cells.As a result,significant antileukemic activity was achieved.The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it.In AML cells,PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.	price>
R-C-1446	GSK8573 CAS:1693766-04-9	GSK8573(compound 23)is an inactive control compound for GSK2801.GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.	price>
R-C-1449	TC-H 106 CAS:937039-45-7	TC-H 106(Pimelic Diphenylamide 106)is a slow,tight-binding inhibitor of class I histone deacetylases(HDAC)with Ki value of 148 nM,about 102 nM,14 nM for HDAC1,HDAC2,HDAC3,respectively.	price>
R-C-1450	UF 010 CAS:537672-41-6	UF-010 is a Class I HDAC inhibitor(IC50 values are 0.06,0.1,0.5 and 1.5μM for HDACs 3,2,1 and 8,respectively).UF010 inhibits cancer cell proliferation via class I HDAC inhibition.This causes global changes in protein acetylation and gene expression,resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways.	price>

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