Product apis-epigentics

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Catalog	name	Description	price
R-C-1562	Mivebresib (ABBV-075) CAS：1445993-26-9	Mivebresib(ABBV-075)is a novel BET family bromodomain inhibitor.It binds bromodomains of BRD2/4/Twith similar affinities(Ki of 1-2.2nM)and highly selective for 18 bromodomain proteins tested (Kd>1μM;more than 600-fold selectivity vs.BRD4),but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM)and has moderate activity towards CREBBP(Kd=87μM;54-fold selectivity vs.BRD4).Mivebresib(ABBV-075)efficiently triggers apoptosis in various tumor cell.	price>
R-C-1590	Apabetalone (RVX-208) CAS:1044870-39-4	Apabetalone(RVX-208)is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.The IC50s are 87 μM and 0.51 μM for BD1 and BD2,respectively.	price>
R-C-1606	Entacapone CAS：130929-57-6	Entacapone(OR-611)inhibits catechol-O-methyltransferase(COMT)with IC50 of 151 nM.Entacapone can be used for the research of Parkinson is disease.Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.	price>
R-C-1626	GSK9311 CAS:1923851-49-3	GSK9311,a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2,respectively.	price>
R-C-1628	GSK2816126 CAS：1346574-57-9	GSK126(GSK2816126A,GSK2816126)is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM,>1000-fold selective for EZH2 over 20 other human methyltransferases.	price>
R-C-1631	GSK2879552 CAS：1401966-69-5	GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1(LSD1/ KDM1A),with potential antineoplastic activity.	price>
R-C-1645	ITSA-1 (ITSA1) CAS:200626-61-5	ITSA-1 is an activator of histone deacetylase(HDAC),and counteract trichostatin A(TSA)-induced cell cycle arrest,histone acetylation,and transcriptional activation.	price>
R-C-1691	UNC0379 CAS：1620401-82-2	UNC0379 is a selective,substrate-competitive inhibitor of the lysine methyltransferase SETD8.Its affinity to SETD8 was confirmed by ITC(isothermal titration calorimetry)and SPR(surface plasmon resonance) studies.	price>
R-C-1713	SGC 707 CAS:1687736-54-4	SGC 707 is a potent allosteric inhibitor of PRMT3(IC50=50 nM)with >100-fold selectivity over other methyltransferases and other non-epigenetic targets.	price>
R-C-1718	Remodelin CAS:949912-58-7	Remodelin is an inhibitor of N-acetyltransferase 10(NAT10),which acetylates both histones and microtubules.Remodelin improves nuclear architecture,chromatin organization,and survival of both cells lacking lamin A and cells from patients with progeria.	price>

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