Product apis-epigentics

Home > products > apis> epigentics

Catalog	name	Description	price
R-C-1452	WDR5 0103 CAS:890190-22-4	WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5(Kd= 450 nM),inhibiting the catalytic activity of the MLL core complex in vitro (IC50=39 µM).WD repeat domain 5(WDR5)plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis.	price>
R-C-1457	NKL 22 CAS:537034-15-4	NKL 22 is a HDAC inhibitor.The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrations NKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes. HDAC inhibitors act directly on FXN.	price>
R-C-1462	PCI 34051 CAS:950762-95-5	PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay.It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2,3,and 10.PCI-34051 induces caspase-dependent apoptosis.	price>
R-C-1490	Decitabine (NSC 127716) CAS：2353-33-5	Decitabine(NSC 127716,Deoxycytidine,Dacogen,5-aza-2-deoxycytidine,5-AZA-dC, 5-aza-CdR)is a DNA methyltransferase inhibitor,incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome(MDS).Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.	price>
R-C-1510	BI-7273 CAS：1883429-21-7	BI-7273 is a selective,and cell-permeable BRD9 inhibitor,with an IC50 and a Kd of 19 and 0.75 nM;also shows high effect on BRD7,with an IC50 and a Kd of 117 nM and 0.3 nM.	price>
R-C-1529	MS023 CAS:1831110-54-3	MS023 is a potent,selective,and cell-active inhibitor of human type I protein arginine methyltransferases(PRMTs)inhibitor,with IC50s of 30,119,83,4 and 5nM for PRMT1,PRMT3,PRMT4,PRMT6,and PRMT8,respectively.	price>
R-C-1530	GSK591（EPZ-015866） CAS:1616391-87-7	GSK591(EPZ015866)is a potent and selective inhibitor of protein methyltransferase 5(PRMT5)with an IC50 of 4 nM.	price>
R-C-1552	C646 CAS NO. 328968-36-1	C646 is an inhibitor for histone acetyltransferase,and inhibits p300 with a Ki of 400 nM in a cell-free assay.Preferentially selective for p300 versus other acetyltransferases.C646 induces cell cycle arrest,apoptosis and autophagy.	price>
R-C-1556	Lirametostat (CPI-1205) CAS:1621862-70-1	Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.	price>
R-C-1560	GSK-6853 CAS：1910124-24-1	GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain.shows excellent BRPF1 potency(pKd 9.5)and greater than 1600-fold selectivity over all other bromodomains tested.	price>

...