Product apis-epigentics

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Catalog	name	Description	price
R-C-1719	AZD5153 6-Hydroxy-2-naphthoic acid CAS:1869912-40-2	AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt)is a potent,selective,and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4.AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3)target genes.NSD3,via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.	price>
R-C-1754	MS049 CAS：2095432-59-8	MS049 is a potent,selective,and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43nM,respectively.MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells.MS049 is not toxic and does not affect the growth of HEK293 cells.	price>
R-C-1758	Toxoflavin CAS:84-82-2	Toxoflavin(Xanthothricin)is an antagonist of transcription factor 4(TCF4)/β-catenin complex,also acts as an inhibitor of KDM4A,with antitumor activity. Antibiotic properties.	price>
R-C-1785	SGC2085 CAS:1821908-48-8	SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1(CARM1)inhibitor with an IC50 value of 50nM and>100-fold selective over other PRMTs.	price>
R-C-1833	UNC3866 CAS:1872382-47-2	UNC3866 is a potent antagonist of the methyllysine(Kme)reading function of the Polycomb CBX and CDY families of chromodomains.UNC3866 binds the chromodomains of CBX4 and CBX7 most potently,with a K(d)of∼100nM for each,and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains.	price>
R-C-1835	MM-102 CAS:1417329-24-8	MM-102(HMTase Inhibitor IX)is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4μM in a cell-free assay.	price>
R-C-1851	Tinostamustine(EDO-S101) CAS:1236199-60-2	EDO-S101(Tinostamustine)is a pan HDAC inhibitor; inhibits HDAC6,HDAC1,HDAC2 and HDAC3 with IC50 values of 6nM,9nM,9nM and 25nM,respectively.	price>
R-C-2257	Alobresib (GS-5829) CAS：1637771-14-2	Alobresib(GS-5829)is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc.Alobresib(GS-5829)inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways,such as BLK,AKT,ERK1/2,and MYC.Alobresib (GS-5829)also inhibits NF-κB signaling.	price>
R-C-1953	KG-501 (2-naphthol-AS-E-phosphate) CAS:18228-17-6	KG-501(2-naphthol-AS-E-phosphate)is a cAMP response element-binding protein (CREB)inhibitor that disrupts CREB-dependent transcription(Ki=10μM)and CREB:CBP interaction(Ki=50μM).It also disrupts phospho(Ser-133)CREB binding to KIX with a Ki of ≈90 μM, using concentrations of CREB that were within the linear range of the binding assay.	price>
R-C-1963	PLX51107 CAS:1627929-55-8	PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6,2.1,1.7, and 5nM for BD1 and 5.9,6.2,6.1,and 120 nM for BD2 of BRD2,BRD3,BRD4,and BRDT, respectively;PLX51107 also interacts with the bromodomains of CBP and EP300(Kd, in the 100nM range).	price>

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