Product apis-epigentics

Home > products > apis> epigentics

Catalog	name	Description	price
R-C-1977	ZL0420 CAS：2229039-45-4	ZL0420 is a potent and selective bromodomain-containing protein 4(BRD4) inhibitor with IC50 values of 27nM against BRD4 BD1 and 32 nM against BRD4 BD2.	price>
R-C-2003	Bobcat339 CAS:2280037-51-4	Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50 of 33uM (TET1)and 73 uM(TET2).Bobcat339 has mid-μM inhibitor activity against TET1 and TET2,but does not inhibit the DNA methyltransferase,DNMT3a.These new molecular tools will be useful to the field of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene transcription.	price>
R-C-2014	MI-503 CAS：1857417-13-0	MI-503 is a potent and selective Menin-MLL inhibitor with IC50=14.7nM.MI-503 shows antitumor activity in in vitro and in vivo models of HCC and reveals the potential mechanism of menin contribution to HCC.	price>
R-C-2022	NCGC00244536 CAS：2003260-55-5	NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10nM.	price>
R-C-2027	PTP1B-IN-1 CAS:612530-44-6	PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B(PTP1B)inhibitor with IC50 of 1.6mM;1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.	price>
R-C-2055	MS417 CAS:916489-36-6	MS417 is a selective BET-specific BRD4 inhibitor,binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30,46nM and Kds of 36.1,25.4nM,respectively,with weak selectivity at CBP BRD(IC50,32.7μM).	price>
R-C-2069	JAK3-IN-6 CAS：1443235-95-7	JAK3-IN-6 is a potent,selective irreversible Janus Associated Kinase 3(JAK3) inhibitor,with an IC50 of 0.15nM.	price>
R-C-2164	PF-06826647 CAS:2127109-84-4	PF-06826647 is an orally active and selective TYK2 inhibitor(IC50=17nM),which binds to TYK2 catalytically active JH1 domain.PF-06826647 displays selectivity for TYK2 over JAK1(IC50=383nM)and JAK2(74nM).PF-06826647 can be used for the research of psoriasis,ulcerative colitis, and hidradenitis suppurativa.	price>
R-C-2169	Panobinostat (LBH589) CAS:404950-80-7	Panobinostat(LBH589,NVP-LBH589)is a novel broad-spectrum HDAC inhibitor with IC50 of 5nM in a cell-free assay.Panobinostat(LBH589) induces autophagy and apoptosis.Panobinostat effectively disrupts HIV latency in vivo.	price>
R-C-2173	Dacinostat (LAQ824) CAS:404951-53-7	Dacinostat(LAQ824)is a hydroxamate histone deacetylase inhibitor with potential anticancer activity.LAQ824 sensitized nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation.	price>

...