Product apis-epigentics

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Catalog	name	Description	price
R-C-461	SRT1720 CAS:1001645-58-4	SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM,and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM,respectively.	price>
R-C-465	ms-275 CAS:209783-80-2	Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays,compared with HDACs 4,6,8,and 10.Entinostat induces autophagy and apoptosis.MS 275 is also offered as part of the Tocriscreen 2.0 Max,Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library.	price>
R-C-477	MGCD0103 CAS:726169-73-9	MGCD0103(Mocetinostat)is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1(HDAC1),but also HDAC2,HDAC3,and HDAC11.It is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2-to10-fold selectivity against HDAC2,3,and 11,and no activity to HDAC4,5,6,7,and 8.Mocetinostat (MGCD0103) induces apoptosis and autophagy.	price>
R-C-615	unc1215 Cas:1415800-43-9	UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor.	price>
R-C-647	CI994 cas:112522-64-2	Tacedinaline(N-acetyldinaline)is an inhibitor of the histone deacetylase(HDAC) with IC50s of 0.9,0.9,1.2μM for recombinant HDAC 1,2 and 3 respectively.	price>
R-C-652	RGFP966	RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM.RGFP966 can penetrate the blood brain barrier(BBB).	price>
R-C-665	GSK343 cas:1346704-33-3	GSK343 is a potent histone H3-lysine 27(H3K27)methyltransferase EZH2 inhibitor (IC= 4 nM).Diplays 1000-fold selectivity for other HMTs except EZH1(60-fold selectivity).GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).	price>
R-C-672	UNC1999 cas: 1431612-23-5	UNC1999 is a potent,orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays,respectively,showin>1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation,differentiation,and apoptosis.	price>
R-C-714	UNC-669 cas:1314241-44-5	UNC669 is a small-molecule antagonist of methyl-lysine(KMe)reader protein with selectivity for L3MBTL1 and L3MBTL3(IC50 of 4.2μM and 3.1μM respectively).	price>
R-R-2426	Pelabresib CAS No.1380087-89-7	Pelabresib (CPI-0610)/CAS No.1380087-89-7 is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC.	price>

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