Product apis-epigentics

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Catalog	name	Description	price
R-R-0332	tert-Butyl-DCL (PSMA inhibitor) CAS:1025796-31-9	Tert-butyl-DCL/CAS:1025796-31-9 is a small molecule inhibitor that targets prostate-specific membrane antigen (PSMA) for potential cancer therapy. PSMA is a cell surface glycoprotein that is highly expressed in prostate cancer cells, making it a promising target for cancer treatment. Tert-butyl-DCL is designed to specifically bind to PSMA and inhibit its activity, which may lead to the suppression of prostate cancer cell growth and proliferation. This inhibitor is currently being studied in preclinical and clinical trials to evaluate its efficacy and safety as a potential treatment for prostate cancer and other PSMA-expressing cancers.	price>
R-C-461	SRT1720 CAS:1001645-58-4	SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM,and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM,respectively.	price>
R-C-465	ms-275 CAS:209783-80-2	Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays,compared with HDACs 4,6,8,and 10.Entinostat induces autophagy and apoptosis.MS 275 is also offered as part of the Tocriscreen 2.0 Max,Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library.	price>
R-C-477	MGCD0103 CAS:726169-73-9	MGCD0103(Mocetinostat)is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1(HDAC1),but also HDAC2,HDAC3,and HDAC11.It is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2-to10-fold selectivity against HDAC2,3,and 11,and no activity to HDAC4,5,6,7,and 8.Mocetinostat (MGCD0103) induces apoptosis and autophagy.	price>
R-C-615	unc1215 Cas:1415800-43-9	UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor.	price>
R-C-647	CI994 cas:112522-64-2	Tacedinaline(N-acetyldinaline)is an inhibitor of the histone deacetylase(HDAC) with IC50s of 0.9,0.9,1.2μM for recombinant HDAC 1,2 and 3 respectively.	price>
R-C-652	RGFP966	RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM.RGFP966 can penetrate the blood brain barrier(BBB).	price>
R-C-665	GSK343 cas:1346704-33-3	GSK343 is a potent histone H3-lysine 27(H3K27)methyltransferase EZH2 inhibitor (IC= 4 nM).Diplays 1000-fold selectivity for other HMTs except EZH1(60-fold selectivity).GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).	price>
R-C-672	UNC1999 cas: 1431612-23-5	UNC1999 is a potent,orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays,respectively,showin>1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation,differentiation,and apoptosis.	price>
R-C-714	UNC-669 cas:1314241-44-5	UNC669 is a small-molecule antagonist of methyl-lysine(KMe)reader protein with selectivity for L3MBTL1 and L3MBTL3(IC50 of 4.2μM and 3.1μM respectively).	price>

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