Product apis-epigentics

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Catalog	name	Description	price
R-R-2437	I-BET151 CAS No.1300031-49-5	I-BET151 (GSK1210151A)/CAS No.1300031-49-5 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.	price>
R-R-2438	ARV-771 CAS No.1949837-12-0	ARV-771/CAS No.1949837-12-0 is a powerful BET degrader based on PROTAC technology with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM for BRD2 (1) , BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2), respectively.	price>
R-R-2439	dBET1 CAS No.1799711-21-9	dBET1/CAS No.1799711-21-9 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker.	price>
R-R-2440	dCBP-1 CAS No.2484739-25-3	dCBP-1/CAS No.2484739-25-3 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression.	price>
R-R-2441	FHD-286 CAS No.2671128-05-3	FHD-286/CAS No.2671128-05-3 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia.	price>
R-R-2442	NSC 228155 CAS No.113104-25-9	NSC 228155/CAS No.113104-25-9 is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits the kinase-inducible domain (KID) of CREB and the KID-interacting domain (KIX) of CBP, with an IC50 of 0.36 μM.	price>
R-R-2443	MG 149 CAS No.1243583-85-8	MG149 (Tip60 HAT inhibitor)/CAS No.1243583-85-8 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM).	price>
R-R-2444	Ziftomenib CAS No.2134675-36-6	Ziftomenib (KO-539)/CAS No.2134675-36-6 is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).	price>
R-R-2445	GNE-781 CAS No.1936422-33-1	GNE-781/CAS No.1936422-33-1 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.	price>
R-R-2446	GSK778 CAS No.2451862-42-1	GSK778 (iBET-BD1)/CAS No.2451862-42-1 is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models.	price>

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