Product apis-epigentics

Home > products > apis> epigentics

Catalog	name	Description	price
R-R-2436	AU-15330 CAS No.2380274-50-8	AU-15330/CAS No.2380274-50-8 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity.	price>
R-R-2437	I-BET151 CAS No.1300031-49-5	I-BET151 (GSK1210151A)/CAS No.1300031-49-5 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.	price>
R-R-2438	ARV-771 CAS No.1949837-12-0	ARV-771/CAS No.1949837-12-0 is a powerful BET degrader based on PROTAC technology with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM for BRD2 (1) , BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2), respectively.	price>
R-R-2439	dBET1 CAS No.1799711-21-9	dBET1/CAS No.1799711-21-9 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker.	price>
R-R-2440	dCBP-1 CAS No.2484739-25-3	dCBP-1/CAS No.2484739-25-3 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression.	price>
R-R-2441	FHD-286 CAS No.2671128-05-3	FHD-286/CAS No.2671128-05-3 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia.	price>
R-R-2442	NSC 228155 CAS No.113104-25-9	NSC 228155/CAS No.113104-25-9 is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits the kinase-inducible domain (KID) of CREB and the KID-interacting domain (KIX) of CBP, with an IC50 of 0.36 μM.	price>
R-R-2443	MG 149 CAS No.1243583-85-8	MG149 (Tip60 HAT inhibitor)/CAS No.1243583-85-8 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM).	price>
R-R-2444	Ziftomenib CAS No.2134675-36-6	Ziftomenib (KO-539)/CAS No.2134675-36-6 is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).	price>
R-R-2445	GNE-781 CAS No.1936422-33-1	GNE-781/CAS No.1936422-33-1 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.	price>

...