Product apis-epigentics

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Catalog	name	Description	price
R-R-2446	GSK778 CAS No.2451862-42-1	GSK778 (iBET-BD1)/CAS No.2451862-42-1 is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models.	price>
R-R-2447	NEO2734 CAS No.2081072-29-7	NEO2734 (EP31670)/CAS No.2081072-29-7 is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains. NEO2734 is active in SPOP mutant and wild-type prostate cancer.	price>
R-R-2448	E-7386 CAS No.1799824-08-0	E-7386/CAS No.1799824-08-0 is an orally active CBP/beta-catenin modulator.	price>
R-R-2449	ZXH-3-26 CAS No.2243076-67-5	ZXH-3-26/CAS No.2243076-67-5 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM.	price>
R-R-2450	BAY-850 CAS No.2099142-76-2	BAY-850/CAS No.2099142-76-2 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.	price>
R-R-2451	GSK046 CAS No.2474876-09-8	GSK046 (iBET-BD2)/CAS No.2474876-09-8 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity.	price>
R-C-752	C7280948 cas:587850-67-7	C-7280948 is a selective and potent protein methyltransferase1(PRMT1)inhibitor with an IC50 value of 12.75 μM.	price>
R-R-2452	dTRIM24 CAS No.2170695-14-2	dTRIM24/CAS No.2170695-14-2 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.	price>
R-R-2453	CPI-637 CAS No.1884712-47-3	CPI-637/CAS No.1884712-47-3 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.	price>
R-R-2454	I-BRD9 CAS No.1714146-59-4	I-BRD9/CAS No.1714146-59-4 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways.	price>

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