Product apis-epigentics

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Catalog	name	Description	price
R-R-2464	FKBP12 PROTAC dTAG-7 CAS No.2064175-32-0	FKBP12 PROTAC dTAG-7 (dTAG-7)/CAS No.2064175-32-0 is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN.	price>
R-R-2465	Trotabresib CAS No.1706738-98-8	CC-90010 (compound 1)/CAS No.1706738-98-8 is a reversible and orally active BET inhibitor. CC-90010 is applied in the study for advanced solid tumors.	price>
R-R-2466	Biotinylated-JQ1 CAS No.1635437-52-3	Biotinylated-JQ1 (Biotin-JQ1)/CAS No.1635437-52-3 is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM.	price>
R-R-2467	A1874 CAS No.2064292-12-0	A1874/CAS No.2064292-12-0 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.	price>
R-R-2468	SGC-SMARCA-BRDVIII CAS No.1997319-84-2	SGC-SMARCA-BRDVIII/CAS No.1997319-84-2 is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts.	price>
R-R-2469	(+)-JQ1 PA CAS No.2115701-93-2	(+)-JQ1 PA/CAS No.2115701-93-2 is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2470	MI-463 CAS No.1628317-18-9	MI-463/CAS No.1628317-18-9 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.	price>
R-R-2471	GSK 4027 CAS No.2079896-25-4	GSK 4027/CAS No.2079896-25-4 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.	price>
R-R-2472	PROTAC BRD9 Degrader-1 CAS No.2097971-01-0	PROTAC BRD9 Degrader-1/CAS No.2097971-01-0 is a PROTAC BRD9 lead chemical degrader (IC50=13.5 nM), which can be used as a useful selective probe for studying the complex biology of BAF.	price>
R-R-2473	BI-9564 CAS No.1883429-22-8	BI-9564/CAS No.1883429-22-8 is a potent, selective and cell-permeable BRD9/BRD7 bromodomains inhibitor, with IC50s of 75 nM and 3.4 μM and Kds of 14 nM and 239 nM, respectively. BI-9564 has an IC50 of > 100 μM for BET family.	price>

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