Product apis-epigentics

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Catalog	name	Description	price
R-R-2483	PF-CBP1 hydrochloride CAS No.2070014-93-4	PF-CBP1 hydrochloride/CAS No.2070014-93-4 is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders.	price>
R-R-2484	BAY1238097 CAS No.1564268-08-1	BAY1238097/CAS No.1564268-08-1 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM).	price>
R-R-2485	(S)-JQ-35 CAS No.1349719-98-7	(S)-JQ-35 (TEN-010)/CAS No.1349719-98-7 is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.	price>
R-R-2486	ACBI2 CAS No.2913161-19-8	ACBI2/CAS No.2913161-19-8 is a highly potent and orally active VHL PROTAC SMARCA2 degrader (EC50: 7 nM), which selectively degrades SMARCA2 with a DC50 value of 1 nM in RKO cells. ACBI2 can be used in the research of lung cancer.	price>
R-R-2487	GSK620 CAS No.2088410-46-0	GSK620/CAS No.2088410-46-0 is a potent and orally active pan-BD2 inhibitor with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.	price>
R-R-2488	MI-538 CAS No.1857417-10-7	MI-538/CAS No.1857417-10-7 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.	price>
R-R-2489	CFT8634 CAS No.2704617-96-7	CFT8634/CAS No.2704617-96-7 is an oral activity degrader targeting BRD9 extracted from patent WO2021178920A1 compound 174. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors.	price>
R-R-2490	INCB-057643 CAS No.1820889-23-3	INCB-057643/CAS No.1820889-23-3 is a novel, orally bioavailable BET inhibitor.	price>
R-R-2491	ZL0454 CAS No.2229042-77-5	ZL0454/CAS No.2229042-77-5 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.	price>
R-R-2492	MI-136 CAS No.1628316-74-4	MI-136/CAS No.1628316-74-4 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors.	price>

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