Product apis-epigentics

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Catalog	name	Description	price
R-R-2494	dBRD9 CAS No.2170679-45-3	dBRD9/CAS No.2170679-45-3,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family.	price>
R-R-2495	PROTAC CBP/P300 Degrader-1 CAS No.2484739-48-0	PROTAC CBP/P300 Degrader-1/CAS No.2484739-48-0 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines.	price>
R-R-2496	FHD-609 CAS No.2676211-64-4	FHD-609/CAS No.2676211-64-4 is an inhibitor and a degrader of BRD9 (bromodomain-containing protein 9). FHD-609 targets to ncBAF, can be used for research of wide range of cancers that contain a mutation in a BAF complex subunit. FHD-609 in combination with Telomelysin or INO5401, may play a role in adrenocortical carcinoma (ACC) treatment.	price>
R-R-2497	I-BET762 carboxylic acid CAS No.1300019-38-8	I-BET762 carboxylic acid (Molibresib carboxylic acid)/CAS No.1300019-38-8 is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.	price>
R-R-2498	TCIP 1 CAS No.3005886-78-9	TCIP 1/CAS No.3005886-78-9 is a transcriptional/epigenetic CIPs (TCIP) small molecule consisting of covalent links to small molecules capable of binding to BCL6 and capable of binding to BRD4, respectively. TCIPs aids cell death gene expression by recruiting endogenous cancer drivers or downstream transcription factors to the promoters of cell death genes. TCIP 1 also plays a gain-of-function mechanism with shows cell specificity and tissue specificity. TCIP 1 forms a gain-of-function ternary complex with BCL6 and BRD4, Inhibits the blocking effect of BCL6 on apoptosis gene, and generates transcriptional extension of pro-apoptotic genes, thus activates apoptosis. TCIP 1 also significantly inhibits the expression of the oncogene MYC and inhibits the growth of diffuse large B-cell lymphoma (DLBCL).	price>
R-R-2499	BPTF-IN-BZ1 CAS No.2766623-38-3	BPTF-IN-BZ1/CAS No.2766623-38-3, a BPTF inhibitor, possesses a high potency (Kd = 6.3 nM).	price>
R-R-2500	GSK-5959 CAS No.901245-65-6	GSK-5959/CAS No.901245-65-6 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC50 of ~ 80 nM.	price>
R-R-2501	FHT-1204 CAS No.2468048-24-8	FHT-1204/CAS No.2468048-24-8 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM (WO2020160180A1; compound 70).	price>
R-R-2502	GNE-064 CAS No.1997321-20-6	GNE-064 (compound 5)/CAS No.1997321-20-6 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis.	price>
R-R-2503	Menin-MLL inhibitor MI-2 CAS No.1271738-62-5	Menin-MLL inhibitor MI-2/CAS No.1271738-62-5 is a Menin-MLL interaction inhibitor with IC50 of 446±28 nM.	price>

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