TCIP 1 CAS No.3005886-78-9

TCIP 1/CAS No.3005886-78-9 is a transcriptional/epigenetic CIPs (TCIP) small molecule consisting of covalent links to small molecules capable of binding to BCL6 and capable of binding to BRD4, respectively. TCIPs aids cell death gene expression by recruiting endogenous cancer drivers or downstream transcription factors to the promoters of cell death genes. TCIP 1 also plays a gain-of-function mechanism with shows cell specificity and tissue specificity. TCIP 1 forms a gain-of-function ternary complex with BCL6 and BRD4, Inhibits the blocking effect of BCL6 on apoptosis gene, and generates transcriptional extension of pro-apoptotic genes, thus activates apoptosis. TCIP 1 also significantly inhibits the expression of the oncogene MYC and inhibits the growth of diffuse large B-cell lymphoma (DLBCL).

msds of TCIP 1 CAS No.3005886-78-9