Product apis-epigentics

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Catalog	name	Description	price
R-R-2504	PROTAC BRD4 Degrader-5 CAS No.2409538-70-9	PROTAC BRD4 Degrader-5/CAS No.2409538-70-9 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines.	price>
R-R-2505	KB02-JQ1 CAS No.2384184-44-3	KB02-JQ1/CAS No.2384184-44-3 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1.	price>
R-R-2506	BAZ1A-IN-1 CAS No.941521-45-5	BAZ1A-IN-1/CAS No.941521-45-5 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A.	price>
R-R-2507	L-Moses CAS No.2079885-05-3	L-Moses (L-45)/CAS No.2079885-05-3 is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM.	price>
R-R-2508	MZP-54 CAS No.2010159-47-2	MZP-54/CAS No.2010159-47-2 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2.	price>
R-R-2509	OF-1 CAS No.919973-83-4	OF-1/CAS No.919973-83-4 is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC50 values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively.	price>
R-R-2510	GNE-207 CAS No.2158266-58-9	GNE-207/CAS No.2158266-58-9 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells.	price>
R-R-2511	MS402 CAS No.1672684-68-2	MS402/CAS No.1672684-68-2 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.	price>
R-R-2512	CBP/p300-IN-1 CAS No.2443789-32-8	CBP/p300-IN-1/CAS No.2443789-32-8 is a CBP/EP300 bromodomain inhibitor.	price>
R-R-2513	HJB97 CAS No.2093391-24-1	HJB97/CAS No.2093391-24-1 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.	price>

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