Product apis-epigentics

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Catalog	name	Description	price
R-R-2514	DN02	DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8(1) (Ki=32 nM), which is 30-fold more affinity than BRD8 (2) (Ki＞1000 nM).	price>
R-R-2515	QCA570 CAS No.2207569-08-0	QCA570/CAS No.2207569-08-0 is a PROTAC connected by ligands for Cereblon and BET, with an IC50 of 10 nM for BRD4 BD1 Protein.	price>
R-R-2516	BRD7-IN-1 CAS No.2448414-48-8	BRD7-IN-1/CAS No.2448414-48-8, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively).	price>
R-R-2517	dBET23 CAS No.1957234-83-1	dBET23/CAS No.1957234-83-1 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein.	price>
R-R-2518	BRD4 Inhibitor-10 CAS No.1660117-38-3	BRD4 Inhibitor-10/CAS No.1660117-38-3 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM.	price>
R-R-2519	AZ13824374	AZ13824374 is a highly potent and selective ATAD2 bromodomain inhibitor which shows cellular target engagement and antiproliferative activity in a range of breast cancer models. AZ13824374 inhibits ATAD2 with pIC50s of 8.2 and 6.2 in ATAD2 FRET assay and ATAD2 NanoBRET assay, respectively.	price>
R-R-2520	GSK8814 CAS No.1997369-78-4	GSK8814/CAS No.1997369-78-4 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1.	price>
R-R-2521	NI-57 CAS No.1883548-89-7	NI-57/CAS No.1883548-89-7 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.	price>
R-R-2522	MT1 CAS No.2060573-82-0	MT1/CAS No.2060573-82-0 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4.	price>
R-R-2523	GNE-375 CAS No.1926989-06-1	GNE-375/CAS No.1926989-06-1 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin.	price>

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