Product apis-epigentics

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Catalog	name	Description	price
R-R-2513	HJB97 CAS No.2093391-24-1	HJB97/CAS No.2093391-24-1 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.	price>
R-R-2514	DN02	DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8(1) (Ki=32 nM), which is 30-fold more affinity than BRD8 (2) (Ki＞1000 nM).	price>
R-R-2515	QCA570 CAS No.2207569-08-0	QCA570/CAS No.2207569-08-0 is a PROTAC connected by ligands for Cereblon and BET, with an IC50 of 10 nM for BRD4 BD1 Protein.	price>
R-R-2516	BRD7-IN-1 CAS No.2448414-48-8	BRD7-IN-1/CAS No.2448414-48-8, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively).	price>
R-R-2517	dBET23 CAS No.1957234-83-1	dBET23/CAS No.1957234-83-1 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein.	price>
R-R-2518	BRD4 Inhibitor-10 CAS No.1660117-38-3	BRD4 Inhibitor-10/CAS No.1660117-38-3 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM.	price>
R-R-2519	AZ13824374	AZ13824374 is a highly potent and selective ATAD2 bromodomain inhibitor which shows cellular target engagement and antiproliferative activity in a range of breast cancer models. AZ13824374 inhibits ATAD2 with pIC50s of 8.2 and 6.2 in ATAD2 FRET assay and ATAD2 NanoBRET assay, respectively.	price>
R-R-2520	GSK8814 CAS No.1997369-78-4	GSK8814/CAS No.1997369-78-4 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1.	price>
R-R-2521	NI-57 CAS No.1883548-89-7	NI-57/CAS No.1883548-89-7 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.	price>
R-R-2522	MT1 CAS No.2060573-82-0	MT1/CAS No.2060573-82-0 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4.	price>

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