Product apis-epigentics

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Catalog	name	Description	price
R-R-2524	I-BET282 CAS No.1422554-34-4	I-BET282/CAS No.1422554-34-4 is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282 shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD).	price>
R-R-2525	MI-3 CAS No.1271738-59-0	MI-3 (Menin-MLL inhibitor 3)/CAS No.1271738-59-0 is a potent and high affinity menin-MLL inhibitor with an IC50 of 648 nM and a Kd of 201 nM.	price>
R-R-2526	ZL0590 CAS No.2230496-99-6	ZL0590/CAS No.2230496-99-6 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities.	price>
R-R-2527	Menin-MLL inhibitor 20 CAS No.2448173-47-3	Menin-MLL inhibitor 20/CAS No.2448173-47-3 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, Intermediate 6).	price>
R-R-2528	GS-626510 CAS No.1637770-13-8	GS-626510/CAS No.1637770-13-8 is a potent, and orally active BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively.	price>
R-R-2529	CBP/p300-IN-8 CAS No.2304416-91-7	CBP/p300-IN-8/CAS No.2304416-91-7 is a potent inhibitor of the CBP/P300 family of bromodomains. CBP/p300-IN-8 inhibits CBP (IC50=0.01-0.1 µΜ) and BRD4 (IC50=1-1000 µΜ) activity.	price>
R-R-2530	NI-42 CAS No.1884640-99-6	NI-42 (compound 13-d)/CAS No.1884640-99-6, a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins.	price>
R-R-2531	M-1211 CAS No.2377337-93-2	M‑1121/CAS No.2377337-93-2 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.	price>
R-R-2532	UNC926 CAS No.1184136-10-4	UNC926/CAS No.1184136-10-4 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM.	price>
R-R-2533	TMX1	TMX1 is a BRD4 covalent molecular glue degrader. TMX1 selectively recruits DCAF16 to BRD4BD2, resulting in the degradation of BRD4.	price>

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