Product apis-epigentics

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Catalog	name	Description	price
R-R-2544	PROTAC BET Degrader-10 CAS No.1957234-97-7	PROTAC BET Degrader-10/CAS No.1957234-97-7 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM.	price>
R-R-2545	MZP-55 CAS No.2010159-48-3	MZP-55/CAS No.2010159-48-3 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 8 nM for Brd4BD2.	price>
R-R-2546	GSK761	GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of CD206+ regulatory macrophages by inhibiting SP140.	price>
R-R-2547	ODM-207 CAS No.1801503-93-4	ODM-207 (BET-IN-4)/CAS No.1801503-93-4 is a potent BET bromodomain protein (BRD4) inhibitor, with an IC50 of ≤ 1 μM.	price>
R-R-2548	Tz-Thalidomide CAS No.2087490-42-2	Tz-Thalidomide/CAS No.2087490-42-2 is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.	price>
R-R-2549	PBRM1-BD2-IN-8 CAS No.2819989-75-6	PBRM1-BD2-IN-8 (compound 34)/CAS No.2819989-75-6 is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity.	price>
R-R-2550	GSK4028 CAS No.2079886-19-2	GSK4028/CAS No.2079886-19-2 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.	price>
R-R-2551	BRM/BRG1 ATP Inhibitor-2 CAS No.2368900-77-8	BRM/BRG1 ATP Inhibitor-2/CAS No.2368900-77-8 is a BRG1/BRM ATPase inhibitor for the research of BAF-related disorders.	price>
R-R-2552	PROTAC BRD4 Degrader-8	PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells.	price>
R-R-2553	LT052 CAS No.2543545-44-2	LT052/CAS No.2543545-44-2 is a highly selective BET BD1 inhibitor with an IC50 of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2 (IC50=12.130 μM). LT052 has anti-inflammatory activity and can be used for acute gout arthritis research.	price>

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