Product apis-epigentics

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Catalog	name	Description	price
R-R-2564	PROTAC BRD4 Degrader-1 CAS No.2133360-00-4	PROTAC BRD4 Degrader-1/CAS No.2133360-00-4 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression.	price>
R-R-2565	XP-524 CAS No.2344825-52-9	XP-524/CAS No.2344825-52-9 is a potent BET and EP300 inhibitor. XP-524 shows great tumoricidal activity in vivo. XP-524 prevents KRAS-induced, neoplastic transformation in vivo and extends survival in two transgenic mouse models of aggressive PDAC. XP-524 also enhances the presentation of self-peptide and tumor recruitment of cytotoxic T lymphocytes. XP-524 has the potential for the research of pancreatic ductal adenocarcinoma (PDAC).	price>
R-R-2566	BET bromodomain inhibitor 1 CAS No.2411226-02-1	BET bromodomain inhibitor 1/CAS No.2411226-02-1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). bromodomain inhibitor 1 has anti-cancer activity.	price>
R-R-2567	GSK1379725A CAS No.1802251-00-8	GSK1379725A/CAS No.1802251-00-8 is a selective BPTF ligand with a Kd of 2.8 uM, showing no binding activity for Brd4.	price>
R-R-2568	UMB298 CAS No.2266569-73-5	UMB298/CAS No.2266569-73-5 is a potent and selective CBP/P300 bromodomain inhibitor.	price>
R-R-2569	BRD4 Inhibitor-24 CAS No.309951-18-6	BRD4 Inhibitor-24 (compound 3U)/CAS No.309951-18-6 is a potent BRD4 inhibitor, BRD4 Inhibitor-24 shows antitumor activity against MCF7 and K652 cells, with IC50 values of 33.7 and 45.9 μM, respectively (extracted from patent CN107721975A).	price>
R-R-2570	SR-0813 CAS No.2597186-19-9	SR-0813/CAS No.2597186-19-9 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia.	price>
R-R-2571	EML 425 CAS No.1675821-32-5	EML425/CAS No.1675821-32-5 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.	price>
R-R-2572	L-Moses dihydrochloride	L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM.	price>
R-R-2573	b-NF-JQ1 CAS No.2380000-55-3	β-NF-JQ1/CAS No.2380000-55-3 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.	price>

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