Product apis-epigentics

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Catalog	name	Description	price
R-R-2584	DC-BPi-03 CAS No.2758411-46-8	DC-BPi-03/CAS No.2758411-46-8 is a potent BPTF-BRD inhibitor with an IC50 of 698.3 nM and a Kd of 2.81 μM.	price>
R-R-2585	BRD4 Inhibitor-20 CAS No.2490311-14-1	BRD4 Inhibitor-20/CAS No.2490311-14-1 is a potent orally active bromodomain protein 4 (BRD4) inhibitor. BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 also has anti-proliferation activities in cancer cell lines. BRD4 Inhibitor-20 can be used for the research of kinds of cancer, such as colon cancer.	price>
R-R-2586	DC-BPi-11 hydrochloride	DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 hydrochloride shows remarkable inhibition against leukemia cell proliferation.	price>
R-R-2587	BET-BAY 002 CAS No.1588521-78-1	BET-BAY 002/CAS No.1588521-78-1 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.	price>
R-R-2588	(R)-BAY1238097 CAS No.1564269-85-7	(R)-BAY1238097/CAS No.1564269-85-7 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome.	price>
R-R-2589	(Rac)-BAY1238097 CAS No.1564268-19-4	(Rac)-BAY1238097/CAS No.1564268-19-4 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research.	price>
R-R-2590	PROTAC BRD4 Degrader-11	PROTAC BRD4 Degrader-11 (compound 9a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.23 nM and 0.38 nM, respectively.	price>
R-R-2591	PROTAC BRD4 Degrader-12 CAS No.2417370-90-0	PROTAC BRD4 Degrader-12 (compound 9c)/CAS No.2417370-90-0 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively.	price>
R-R-2592	MS31 CAS No.2366264-12-0	MS31/CAS No.2366264-12-0 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells.	price>
R-R-2593	PROTAC BRD4 Degrader-9 CAS No.2417370-42-2	PROTAC BRD4 Degrader-9 (compound 8a)/CAS No.2417370-42-2 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively.	price>

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