Product apis-epigentics

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Catalog	name	Description	price
R-R-2594	Menin-MLL inhibitor 19 CAS No.2360487-93-8	Menin-MLL inhibitor 19/CAS No.2360487-93-8, a potent exo-aza spiro inhibitor of menin-mll interaction, example A17, extracted from patent WO2019120209A1. Menin-MLL inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes.	price>
R-R-2595	GSK973 CAS No.2138473-38-6	GSK973/CAS No.2138473-38-6 is a highly selective, orally bioavailable inhibitor of the BD2s (second bromodomains) of the BET family, with a pIC50 of 7.8 and a pKd of 8.7 for BRD4 BD2. GSK973 displays a 1600-fold selectivity for BRD4 BD2 over BRD4 BD1. GSK973 shows good potency against BRD2 BD2, BRD3 BD2, and BRDT BD2 (pIC50=7.4~7.8; pKd=8.3~8.5).	price>
R-R-2596	PROTAC BET degrader-2 CAS No.2093388-33-9	PROTAC BET degrader-2/CAS No.2093388-33-9 is a PROTAC connected by ligands for Cereblon and BET with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.	price>
R-R-2597	TP-238 hydrochloride CAS No.2415263-05-5	TP-238 hydrochloride/CAS No.2415263-05-5 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases.	price>
R-R-2598	CBP/p300-IN-20	CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 can be used for the research of cancer.	price>
R-R-2599	Naringenin triacetate CAS No.3682-04-0	Naringenin triacetate/CAS No.3682-04-0 is a flavonoid isolated from plant, exhibits a good binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1).	price>
R-R-2600	Phoenixin-20 CAS No.1415039-77-8	Phoenixin-20 (PNX-20)/CAS No.1415039-77-8 is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect.	price>
R-R-2601	Luteolin 7-sulfate CAS No.56857-57-9	Luteolin 7-sulfate/CAS No.56857-57-9 is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis.	price>
R-R-2602	IV-255	IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide.	price>
R-R-2603	iBRD4-BD1 diTFA CAS No.2839318-20-4	iBRD4-BD1 diTFA/CAS No.2839318-20-4 is selective BRD4 bromodomain inhibitor. iBRD4-BD1 diTFA has inhibition activity for BRD4 bromodomain with an IC50 value of 12 nM. iBRD4-BD1 diTFA can be used for the research of inflammation and oncology.	price>

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