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Catalog	name	Description	price
R-C-1015	CPI203 CAS No. 1446144-04-2	CPI203 is an analog of the BET inhibitor(BETi)(+)-JQ1 and is bioavailable via oral or intraperitoneal administration.It plays an important role in lenalidomide and dexamethasone functions in in vitro and in vivo models of multiple myeloma.CPI203 inhibits proliferation,apoptosis and cell cycle arrest in A431 cell line and primary skin squamous cell carcinoma(SCC)cells.CPI203 is an inhibitor of BRD4,a bromodomain-containing protein that binds to histones to regulate recruitment of transcription factors.BRD4 is also an RNA Pol II kinase. CPI203 blocks BRD4 kinase activity in cells and in vivo.It has shown synergistic antitumor activity with lenalidomide in bortezomib-resistant mantle cell lymphoma.	price>
R-C-1017	JQ-1 CAS NO. 202592-23-2	JQ-1 carboxylic acid is a(+)-JQ1 derivative(a BET bromodomain inhibitor).JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs,which targets BET bromodomains.	price>
R-C-1024	TMP269 CAS No. 1314890-29-3	TMP269 is a novel and selective class IIa histone deacetylase(HDAC)inhibitor with IC50s of 157 nM,97nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9, respectively.	price>
R-C-1030	Valrubicin CAS No. 56124-62-0	Valrubicin is a chemotherapy drug used to treat bladder cancer.Valrubicin is a chemotherapy agent,inhibits TPA-and PDBu-induced PKC activation with IC50s of 0.85 and 1.25μM,respectively.	price>
R-C-1039	GSK126 CAS No. 1346574-57-9	GSK126 is a potent,highlyselective,S-adenosyl-methionine-competitive,small-molecule inhibitor of EZH2 methyltransferase activity,decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.	price>
R-C-1046	Tofacinix CAS:477600-75-2	Tofacitinib is an orally available inhibitor of Janus kinases(JAK),with immunomodulatory and anti-inflammatory activities.Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription(STAT)signaling pathway.This may decrease the production of pro-inflammatory cytokines,such as interleukin (IL)-6,-7,-15,-21,interferon-alpha and -beta, and may prevent both an inflammator response and the inflammation-induced damage caused by certain immunological diseases.JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis,immunity and inflammation.	price>
R-C-1053	Tazemetostat (EPZ-6438) CAS No. 1403254-99-8	Tazemetostat(EPZ-6438,E7438)is a potent,and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays,exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.	price>
R-C-1054	EPz005687 CAS:1396772-26-1	EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM,and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.	price>
R-C-1063	PFI-3 CAS:1819363-80-8	PFI-3 is a selective chemical probe for SMARCA bromodomains,including SMARCA2, SMARCA4 and PB1(5)bromodomains.	price>
R-C-1092	Citarinostat (ACY-241) CAS：1316215-12-9	Citarinostat(ACY-241,HDAC-IN-2)is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3,respectively.It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.	price>

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