Product apis-epigentics

Home > products > apis> epigentics

Catalog	name	Description	price
R-C-1017	JQ-1 CAS NO. 202592-23-2	JQ-1 carboxylic acid is a(+)-JQ1 derivative(a BET bromodomain inhibitor).JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs,which targets BET bromodomains.	price>
R-C-1024	TMP269 CAS No. 1314890-29-3	TMP269 is a novel and selective class IIa histone deacetylase(HDAC)inhibitor with IC50s of 157 nM,97nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9, respectively.	price>
R-C-1030	Valrubicin CAS No. 56124-62-0	Valrubicin is a chemotherapy drug used to treat bladder cancer.Valrubicin is a chemotherapy agent,inhibits TPA-and PDBu-induced PKC activation with IC50s of 0.85 and 1.25μM,respectively.	price>
R-C-1039	GSK126 CAS No. 1346574-57-9	GSK126 is a potent,highlyselective,S-adenosyl-methionine-competitive,small-molecule inhibitor of EZH2 methyltransferase activity,decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.	price>
R-C-1046	Tofacinix CAS:477600-75-2	Tofacitinib is an orally available inhibitor of Janus kinases(JAK),with immunomodulatory and anti-inflammatory activities.Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription(STAT)signaling pathway.This may decrease the production of pro-inflammatory cytokines,such as interleukin (IL)-6,-7,-15,-21,interferon-alpha and -beta, and may prevent both an inflammator response and the inflammation-induced damage caused by certain immunological diseases.JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis,immunity and inflammation.	price>
R-C-1053	Tazemetostat (EPZ-6438) CAS No. 1403254-99-8	Tazemetostat(EPZ-6438,E7438)is a potent,and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays,exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.	price>
R-C-1054	EPz005687 CAS:1396772-26-1	EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM,and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.	price>
R-C-1063	PFI-3 CAS:1819363-80-8	PFI-3 is a selective chemical probe for SMARCA bromodomains,including SMARCA2, SMARCA4 and PB1(5)bromodomains.	price>
R-C-1092	Citarinostat (ACY-241) CAS：1316215-12-9	Citarinostat(ACY-241,HDAC-IN-2)is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3,respectively.It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.	price>
R-C-1098	Resminostat CAS：864814-88-0	Resminostat,also known as RAS2410,is a potent inhibitor of histone deacetylase (HDAC)classes I and II.It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.	price>

...