Product apis-epigentics

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Catalog	name	Description	price
R-C-1112	ML234 CAS: 1222800-79-4	ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.	price>
R-C-1122	EPZ015666 (GSK3235025) CAS:1616391-65-1	Protein arginine methyltransferases(PRMTs)target nuclear and cytoplasmic substrates and can alter protein actions and gene expression.PRMT5,which can methylate histones H2A,H3,and H4,ribonucleoproteins,and other proteins,is upregulated in several human cancers,including lymphomas.Moreover,suppression of PRMT5 expression induces lymphoma cell death.EPZ015666 is a potent,orally bioavailable inhibitor of PRMT5(Ki=5nM).It displays more than 20,000-fold selectivity for PRMT5 over other PMTs.EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50,which is necessary for the formation of an active methyltransferase complex.	price>
R-C-1125	SP2509 CAS:1423715-09-6	Soluble in DMSO.LSD1 is a promising target for cancer therapy.Epigenetic control of histone methylation is frequently associated with oncogenesis and LSD1 is overexpressed in many types of cancer.siRNA knockdown of LSD1 has been shown to suppress growth of cancer cells.SP-2528 is a selective and reversible LSD1 inhibitor with an IC(50)of 10nM.SP-2528 demonstrates a high specificity for LSD1,with no effect on MAOi.Target:LSD1.	price>
R-C-1133	GSKJ1 CAS :1373422-53-7	GSKJ1 is a selective and potent histone demethylase inhibitor(GSK-J1)that has significant activity(IC50 60 nM for human JmjD3)in vitro and in cells using an ester derivative(GSK-J4:1 µM	price>
R-C-1146	BIX01294 HCl CAS：1392399-03-9	BIX01294 is a potent chemical inhibitor of G9a methyltransferase that catalyzes the mono-and di-methylation of the lysine 9 residue of histone H3.BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7cells. BIX01294 enhances the cardiac potential of bone marrow cells.	price>
R-C-1178	GSK503 CAS：1346572-63-1	GSK503 is a potent and specific inhibitor of EZH2 methyltransferase with Kiapp values of 3 to 27 nM.	price>
R-C-1195	GSK-LSD1 CAS:2102933-95-7	GSK-LSD1 dihydrochloride is a potent,selective and irreversible lysine specific demethylase 1(LSD1)inhibitor with an IC50 of 16 nM.	price>
R-C-1196	ORY-1001 CAS：1431326-61-2	ORY-1001 is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM,with high selectivity against related FAD dependent aminoxidases.	price>
R-C-1199	IBET762(GSK525762A) CAS ：1260907-17-2	Molibresib(I-BET-762,GSK525762,GSK525762A)is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay,suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation,highly selective over other bromodomain-containing proteins.	price>
R-C-1206	OTX015 CAS:202590-98-5	Birabresib(OTX015,MK 8628)is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2,BRD3,and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3(NSD3)target genes.	price>

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