Product apis-epigentics

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Catalog	name	Description	price
R-C-1229	GSK8573 CAS :1693766-04-9	GSK8573(compound 23)is an inactive control compound for GSK2801.GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.	price>
R-C-1243	CPI-169 CAS:1450655-76-1	CPI-169(CPI 169 R-enantiomer)is a novel and potent EZH2 inhibitor,with IC50s of 0.24 nM,0.51 nM,and 6.1nM for EZH2 WT,EZH2 Y641N,and EZH1,respectively.	price>
R-C-1244	cpi-360 CAS:1802175-06-9	CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2,respectively.	price>
R-C-1253	Tubastatin A(free base) CAS：1252003-15-8	Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A demonstrates 1093-fold selectivity over HDAC1(IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1).Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8.	price>
R-C-1259	MS436 CAS No. 1395084-25-9	MS436 is a BRD4 inhibitor.MS436,through a set of water-mediated interactions, exhibits low nanomolar affinity(estimated Ki of 30-50 nM).MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages.	price>
R-C-1260	BRD4770 CAS：1374601-40-7	BRD4770 is a histone methyltransferase G9a inhibitor.BRD4770 reduces di- and trimethylation of lysine 9 on histone H3(H3K9)with an EC50 of 5 µM,and has less or little effect toward H3K27me3,H3K36me3,H3K4me3,and H3K79me3.BRD4770 can activate the ataxia telangiectasia mutated(ATM)pathway and induce cell senescence.	price>
R-C-1262	GSK 525762A (I-BET-762) CAS：1260907-17-2	GSK-525762A is a small molecule inhibitor of the BET(Bromodomain and Extra-Terminal)family.	price>
R-C-1265	BIX 01294 CAS：1392399-03-9	BIX01294 is a potent chemical inhibitor of G9a methyltransferase that catalyzes the mono-and di-methylation of the lysine 9 residue of histone H3.BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7cells. BIX01294 enhances the cardiac potential of bone marrow cells.	price>
R-C-1295	BAZ2-ICR CAS:1665195-94-7	BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo.The bromodomain containing proteins BAZ2A/B play essential roles in chromatin remodeling and regulation of noncoding RNAs. BAZ2-ICR has IC50(BAZ2A)=130 nM;IC50(BAZ2B)=180 nM;logD=1.05;solubility 25 mM (D2O)and F=70%.	price>
R-C-1310	Domatinostat (4SC-202） CAS：910462-43-0	Domatinostat(4SC-202 free base)is a selective class I HDAC inhibitor with IC50 of 1.20 μM,1.12 μM,and 0.57 μM for HDAC1,HDAC2,and HDAC3, respectively.It also displays inhibitory activity against Lysine specific demethylase 1(LSD1).	price>

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