Product apis-epigentics

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Catalog	name	Description	price
R-R-2604	ZEN-3219 CAS No.1952264-34-4	ZEN-3219/CAS No.1952264-34-4 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4.	price>
R-R-2605	(+)-JQ-1-aldehyde CAS No.2634778-37-1	(+)-JQ-1-aldehyde/CAS No.2634778-37-1 is the aldehyde form of (+)-JQ1. (+)-JQ-1-aldehyde can be uesd as a precursor to synthesize PROTACs, which targets BET bromodomains.	price>
R-R-2606	OXFBD04 CAS No.2231747-03-6	OXFBD04/CAS No.2231747-03-6 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity.	price>
R-R-2607	Menin-MLL inhibitor-22 CAS No.2851841-61-5	Menin-MLL inhibitor-22 (compound C20)/CAS No.2851841-61-5 is an orally active inhibitor of the interaction between menin and mixed lineage leukemia (MLL) (IC50=7 nM). Menin-MLL inhibitor-22 binds menin protein and inhibits cancer cell growth (MV4 cells, IC50=0.3 μM). Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).	price>
R-R-2608	PROTAC BRD4 Degrader-10 CAS No.2417370-49-9	PROTAC BRD4 Degrader-10 (compound 8b)/CAS No.2417370-49-9 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively.	price>
R-R-2609	Bromodomain inhibitor-8 CAS No.1300031-70-2	Bromodomain inhibitor-8 (Intermediate 21)/CAS No.1300031-70-2 is a BET bromodomain inhibitor for treating autoimmune and inflammatory diseases.	price>
R-R-2610	UNC1021 CAS No.1322591-19-4	UNC1021/CAS No.1322591-19-4 is a selective L3MBTL3 inhibitor with an IC50 of 0.048 μM.	price>
R-R-2611	PROTAC BRD9 Degrader-6 CAS No.2676211-62-2	PROTAC BRD9 Degrader-6/CAS No.2676211-62-2 is a potent degrader of BRD9 (IC50=0.13 nM), can be used for research of BAF complex-related disorders.	price>
R-C-1008	PFI-1 (PF-6405761) cas:1403764-72-6	PFI-1(PF-6405761)is a highly selective BET(bromodomain-containing protein)inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.	price>
R-C-1015	CPI203 CAS No. 1446144-04-2	CPI203 is an analog of the BET inhibitor(BETi)(+)-JQ1 and is bioavailable via oral or intraperitoneal administration.It plays an important role in lenalidomide and dexamethasone functions in in vitro and in vivo models of multiple myeloma.CPI203 inhibits proliferation,apoptosis and cell cycle arrest in A431 cell line and primary skin squamous cell carcinoma(SCC)cells.CPI203 is an inhibitor of BRD4,a bromodomain-containing protein that binds to histones to regulate recruitment of transcription factors.BRD4 is also an RNA Pol II kinase. CPI203 blocks BRD4 kinase activity in cells and in vivo.It has shown synergistic antitumor activity with lenalidomide in bortezomib-resistant mantle cell lymphoma.	price>

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