Product apis-epigentics

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Catalog	name	Description	price
R-R-2574	GSK852 CAS No.2305842-30-0	GSK852/CAS No.2305842-30-0 is a highly potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitor (pIC50 = 7.9).	price>
R-R-2575	OARV-771 CAS No.2683008-37-7	OARV-771/CAS No.2683008-37-7 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively.	price>
R-R-2576	I-BET567 CAS No.1887237-54-8	I-BET567/CAS No.1887237-54-8 is a potent and orally active inhibitor of pan-BET candidate with pIC50s of 6.9 and 7.2 for BRD4 BD1 and BD2, respectively. I-BET567 has been demonstrated efficacy in mouse models of oncology and inflammation.	price>
R-R-2577	Y06137 CAS No.2226534-49-0	Y06137/CAS No.2226534-49-0 is a potent and selective BET inhibitor for treatment of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomain with a Kd of 81 nM.	price>
R-R-2578	BET bromodomain inhibitor CAS No.1505453-59-7	BET bromodomain inhibitor/CAS No.1505453-59-7 is a potent BET inhibitor extracted from patent WO/2015/153871A2, compound example 11.	price>
R-R-2579	Thalidomide-NH-CBP/p300 ligand 2 CAS No.2484739-21-9	Thalidomide-NH-CBP/p300 ligand 2 (P-007)/CAS No.2484739-21-9 is a PROTAC-based CBP and p300 degrader (extracted from patent WO2020173440).	price>
R-R-2580	CF53 CAS No.1808160-52-2	CF53/CAS No.1808160-52-2 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo.	price>
R-R-2581	Y06036 CAS No.1832671-96-1	Y06036/CAS No.1832671-96-1 is a potent and selective BET inhibitor, which binds to the BRD4(1) bromodomain with Kd value of 82 nM. Antitumor activity.	price>
R-R-2582	BET-IN-14 CAS No.2243669-93-2	BET-IN-14/CAS No.2243669-93-2 is an orally active pan BET inhibitor (IC50: 5.35 nM). BET-IN-14 has anti-cancer activity.	price>
R-R-2583	iBRD4-BD1 CAS No.2839318-17-9	iBRD4-BD1/CAS No.2839318-17-9 is selective BRD4 bromodomain inhibitor. iBRD4-BD1 has inhibition activity for BRD4 bromodomain with an IC50 value of 12 nM. iBRD4-BD1 can be used for the research of inflammation and oncology.	price>

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