Product apis-epigentics

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Catalog	name	Description	price
R-R-2554	BETd-246 CAS No.2140289-17-2	BETd-246/CAS No.2140289-17-2 is a second-generation and PROTAC-based BET bromodomain (BRD) inhibitor connected by ligands for Cereblon and BET, exhibiting superior selectivity, potency and antitumor activity.	price>
R-R-2555	PROTAC BET degrader-3	PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.	price>
R-R-2556	LP99 CAS No.1808951-93-0	LP99/CAS No.1808951-93-0, an epigenetic probe, is a potent and selective inhibitor of the BRD7 and BRD9 bromodomains with a Kd of 99 nM against BRD9. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells.	price>
R-R-2557	RVX-297 CAS No.1044871-04-6	RVX-297/CAS No.1044871-04-6 is a potent, orally active BET bromodomain inhibitor with selectivity for BD2. RVX-297 shows IC50s of 0.08, 0.05, and 0.02 μM for BRD2(BD2), BRD3(BD2), and BRD4(BD2), respectively. RVX-297 suppresses inflammatory gene expression in multiple immune cell types. RVX-297 is effective in acute inflammation and autoimmunity models.	price>
R-R-2558	Bleximenib oxalate CAS No.2866179-95-3	Bleximenib oxalate/Menin-MLL inhibitor 24 (compound A) oxalate/CAS No.2866179-95-3 is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer.	price>
R-R-2559	PROTAC BRD4-binding moiety 1 CAS No.2101200-10-4	PROTAC BRD4-binding moiety 1/CAS No.2101200-10-4 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136). PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2560	653-47 hydrochloride CAS No.1224567-46-7	653-47 hydrochloride/CAS No.1224567-46-7, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM.	price>
R-R-2561	XX-650-23 CAS No.117739-40-9	XX-650-23/CAS No.117739-40-9 is a potent CREB inhibitor. XX-650-23inhibits CREB function through disruption of CBP-CREB interaction. XX-650-23 can be used for AML research.	price>
R-R-2562	PBRM1-BD2-IN-5 CAS No.2819989-61-0	PBRM1-BD2-IN-5/CAS No.2819989-61-0 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer.	price>
R-R-2563	INCB054329 CAS No.1628607-64-6	INCB054329/CAS No.1628607-64-6 is a potent BET inhibitor.	price>

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