Product apis-epigentics

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Catalog	name	Description	price
R-R-2534	Naphthol AS-E CAS No.92-78-4	Naphthol AS-E/CAS No.92-78-4 is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research.	price>
R-R-2535	MI-2-2 CAS No.1454920-20-7	MI-2-2/CAS No.1454920-20-7 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.	price>
R-R-2536	TPOP146 CAS No.2018300-62-2	TPOP146/CAS No.2018300-62-2 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.	price>
R-R-2537	M-89 CAS No.2363165-42-6	M-89/CAS No.2363165-42-6 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.	price>
R-R-2538	Amredobresib CAS No.1610044-98-8	Amredobresib/CAS No.1610044-98-8 is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1).	price>
R-R-2539	FL-411 CAS No.2118944-88-8	FL-411/CAS No.2118944-88-8 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.	price>
R-R-2540	PROTAC BET Degrader-1 CAS No.2093386-22-0	PROTAC BET Degrader-1/CAS No.2093386-22-0 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.	price>
R-R-2541	SNIPER(BRD)-1 CAS No.2095244-54-3	SNIPER(BRD)-1/CAS No.2095244-54-3, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.	price>
R-R-2542	CeMMEC1 CAS No.440662-09-9	CeMMEC1/CAS No.440662-09-9 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 .	price>
R-R-2543	Molibresib besylate CAS No.1895049-20-3	Molibresib besylate (GSK 525762C; I-BET 762 besylate)/CAS No.1895049-20-3 is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.	price>

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