GSKJ4HCL CAS No. 1797983-09-5

GSK-J4 is a cell permeable,potent and selective histone demethylase.GSK-J4 is a prodrug of GSK J1,which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.GSK-J4 is used to probe the consequences of demethylation of H3K27me3.GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines,including pro-inflammatory tumour necrosis facto(TNF).

msds---GSKJ4HCL