HLCL-61 HCL CAS：1158279-20-9

HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia.HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML(acute myeloid leukemia)cells.As a result,significant antileukemic activity was achieved.The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it.In AML cells,PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.

msds---HLCL-61 HCL