Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-C-1164	GW9662 CAS: 22978-25-2	GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ,respectively.	price>
R-C-1207	AZD2461 CAS:1174043-16-3	AZD-2461 is a potent PARP inhibitor,with IC50s of 5 nM,2 nM and 200 nM for PARP1,PARP2 and PARP3,respectively.	price>
R-C-1221	TH287 CAS：1609960-30-6	TH287 is a potent and selective inhibitor of MTH1,with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1,with no relevant inhibition of MTH2, NUDT5,NUDT12,NUDT14,NUDT16,dCTPase,dUTPase and ITPA at 100 μM.TH287 could act as a chemotherapeutic agent for cancer research.	price>
R-C-1232	Lomeguqtrib CAS:192441-08-0	Lomeguatrib,also known as PaTrin-2,is a potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase.Lomeguatrib is also a nontoxic low-molecular weight pseudosubstrate that has the ability to inactivate MGMT.Lomeguatrib can be used with temozolomide(TMZ)for GBM treatment.	price>
R-C-1235	BRD73954 CAS:1440209-96-0	BRD73954 is a small molecule inhibitor that potently inhibits HDAC6 and HDAC8. It inhibits HDAC6,a class IIb histone that deacetylates cytoplasmic proteins, including tubulin,heat shock protein 90,and cortactin,and has roles in cell adhesion and motility.It is also an inhibitor of HDAC8,a class I histone that primarily targets nuclear proteins,including histones and cohesins,and regulates gene expression.	price>
R-C-1377	Topotecan CAS:123948-87-8	Topotecan(SKF 104864A;NSC 609669)is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells,2.95±0.23 μM of U87 cells,5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.	price>
R-C-1384	Voreloxin CAS:175414-77-4	Voreloxin,also known as SNS-595 or Vosaroxin,is a s mall molecule and a naphthyridine analogue with antineoplastic activity.Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result,inhibition of DNA replication,RNA and protein synthesis occurs,followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis.This agent shows a favorable toxicity profile in several aspects:it does not generate reactive oxygen species,as do anthracyclines,reducing the risk of cardiotoxicity.	price>
R-C-1444	Santacruzamate A (CAY10683) CAS:1477949-42-0	Santacruzamate A(CAY10683)is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2,>3600-fold selectivity over other HDACs.	price>
R-C-1445	PRE-084 hydrochloride CAS:75136-54-8	AZ084 is a potent,selective,allosteric and oral active CCR8 antagonist,with a Ki of 0.9 nM.Has potential to treat asthma.	price>
R-C-1453	MN 64 CAS:92831-11-3	MN-64 is a potent tankyrase 1 inhibitor,with IC50s of 6 nM,72 nM,19.1μM,and 39.4μM for TNKS1,TNKS2,ARTD1 and ARTD2,respectively.	price>

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