Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-C-730	UPF-1069 CAS NO. 1048371-03-4	UPF 1069 is a selective poly(ADP-ribose)polymerase (PARP)2 inhibitor(IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).	price>
R-C-733	MK4827 CAS No. 1038915-60-4	Niraparib(MK-4827)is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM,respectively.Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.	price>
R-C-1005	TAS-103 cas:174634-08-3	TAS-103 is a dual inhibitor of DNA topoisomerase I/II,used for cancer research.	price>
R-C-1009	GNZ-644282 cas:529488-28-6	Genz-644282 is a non-camptothecin topoisomerase I(Topo I)inhibitor that demonstrates potent cytotoxic activity with a median IC50 of 1.2 nM(range 0.2 nM-21.9 nM).Genz-644282 can be used in cancer research.	price>
R-C-1014	TMP-269 cas:1314890-29-3	TMP 269 is a potent,selective class IIa HDAC inhibitor with IC50 of 157 nM,97 nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9,respectively.	price>
R-C-1025	Nexturastat A CAS No. 1403783-31-2	Nexturastat A is a selective inhibitor of histone deacetylase 6(HDAC6)with IC50 value of 5.2 nM.Nexturastat A is a HDAC inhibitor.It was developed by structural modification of aryl urea HDACIs.The inhibitory activity of Nexturastat A is most potent against HDAC6 with IC50 value of 5.2 nM. Besides that,Nexturastat A also shows inhibition of other HDACs with IC50 values of 3.02,6.92,6.68,9.39, 11.7,4.46,0.954,6.72,7.57and5.14μM for HDAC1,2,3,4,5,7,8,9,10 and 11,respectively.Nexturastat A has been shown to suppress cell proliferation and promote apoptosis in B16 murine melanoma cells.	price>
R-C-1031	Pirarubicin CAS No. 72496-41-4	Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II(topoisomerase II)and supressing DNA replication.	price>
R-C-1041	Mitomycin C CAS:50-07-7	Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis,used to treat different cancers.Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.	price>
R-C-1051	A966492 CAS:934162-61-5	A-966492 displayed high potency against the poly(ADP-ribose)polymerase-1 (PARP-1)enzyme with a K(i)of 1 nM and an EC(50) of 1 nM in a whole cell assay.	price>
R-C-1075	BMH-21 CAS：896705-16-1	BMH-21 is a potent small molecule DNA intercalator.BMH-21 binds ribosomal DNA and inhibits RNA polymerase I(Pol I)transcription.	price>

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