Voreloxin CAS:175414-77-4

Voreloxin,also known as SNS-595 or Vosaroxin,is a s mall molecule and a naphthyridine analogue with antineoplastic activity.Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result,inhibition of DNA replication,RNA and protein synthesis occurs,followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis.This agent shows a favorable toxicity profile in several aspects:it does not generate reactive oxygen species,as do anthracyclines,reducing the risk of cardiotoxicity.

msds---Voreloxin