Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-C-1671	Salermide CAS：1105698-15-4	Salermide is a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.Salermide was well tolerated by mice at concentrations up to 100 muM and prompted tumour-specific cell death in a wide range of human cancer cell lines.The antitumour activity of Salermide was primarily because of a massive induction of apoptosis.	price>
R-C-1687	NMS-P118 CAS：1262417-51-5	NMS-P118 is a potent,orally available,and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles,showing 150-fold selectivity for PARP-1 over PARP-2(Kd 0.009μM vs 1.3μM,respectively).	price>
R-C-1695	E 7449 CAS：1140964-99-3	E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2,with IC50s of 2.0,1.0,∼50 and∼50 nM for PARP1,PARP2,TNKS1 and TNKS2,respectively,using 32P-NAD+ as substrate.	price>
R-C-1699	SRT-2104 CAS：1093403-33-8	SRT 2104 is a first-in-class,highly selective and brain-permeable activator of the NAD+dependent deacetylase Sirt1,increases Sirt1 protein,but shows no effect on Sirt1 mRNA.Used in the research of diabetes mellitus and Huntington is disease.	price>
R-C-1712	CX5461 CAS:1138549-36-6	Pidnarulex(CX-5461)is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116,A375,and MIA PaCa-2 cells,has no effect on Pol II,and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.	price>
R-C-1728	Doxorubicin (Adriamycin) HCl CAS:25316-40-9	Doxorubicin(Adriamycin,NSC 123127,DOX,Hydroxydaunorubicin)HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage,mitophagy and apoptosis in tumor cells.Doxorubicin reduces basal phosphorylation of AMPK.Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.	price>
R-C-1738	Talazoparib (BMN 673) CAS:1207456-01-6	Talazoparib(BMN-673)is a highly potent,orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2nM and 0.87nM,respectively.Talazoparib has antitumor activity.	price>
R-C-1786	WIKI4 CAS:838818-26-1	WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM.WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2.WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02μM.	price>
R-C-1890	Pritelivir (BAY 57-1293） CAS：348086-71-5	BAY 57-1293 is a potent helicase primase inhibitor.BAY 57-1293 inhibits replication of herpes simplex virus(HSV)type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex.	price>
R-C-1951	4μ8C CAS:14003-96-4	4μ8C(IRE1 Inhibitor III)is a IRE1 Inhibitor.4µ8C inhibits IRE1α splicing of Xbp1 mRNA(IC50=6.8µM)and reduces subsequent gene expression of Erdj4 (IC50=3.4µM)in stress-cultured MEF cells but does not block IRE1α autophosphorylation.	price>

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