Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-C-2159	E3330 CAS:136164-66-4	E3330(APX-3330)is a direct,orally active and selective AP endonuclease 1(APE1; REF-1)inhibitor,which suppresses NF-κB DNA-binding activity.E3330(APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330(APX-3330)shows anticancer properties,such as inhibition of cancer cell growth and migration.	price>
R-C-2161	AZD7648 CAS:2230820-11-6	AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6nM in biochemical assay and more than 100-fold selective against 396 other kinases.	price>
R-C-2170	ACY-775 CAS:1375466-18-4	ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6)with an IC50 of 7.5nM.	price>
R-C-2267	SCR130 CAS: 2377858-38-1	SCR130 is a novel DNA repair inhibitor with IC50s of 14μM in Reh cells and 2μM in Nalm6 cells.SCR130 specifically inhibits DNA Ligase IV mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.	price>
R-C-2268	PFM01 CAS:1558598-41-6	PFM01,N-alkylated Mirin derivative,is a MRE11 endonuclease inhibitor.PFM01 can regulate double-strand break repair(DSBR)by nonhomologous end-joining (NHEJ)versus homologous recombination(HR).	price>
R-C-2269	Metarrestin (ML246) CAS:1443414-10-5	Metarrestin(ML246)is an orally active and specific perinucleolar compartment (PNC)inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase(Pol)I transcription.Metarrestin blocks metastatic development and extends survival in mouse cancer models.	price>
R-C-2270	Menthone CAS:10458-14-7	Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.).Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.	price>
R-C-2273	Capecitabine(RO 09-1978) CAS:154361-50-9	Capecitabine(RO 09-1978)is a tumor-selective fluoropyrimidine carbamate,which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.	price>
R-C-2274	Cidofovir CAS: 113852-37-2	Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.	price>
R-C-2275	Cytarabine (U-19920A) CAS:147-94-4	Cytarabine(U-19920A,Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459)is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.Cytarabine induces autophagy and apoptosis.	price>

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