Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-C-2276	Gemcitabine (LY-188011) CAS:95058-81-4	Gemcitabine(LY 188011)is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent.Gemcitabine inhibits DNA synthesis and repair,resulting in autophagyand apoptosis.	price>
R-C-2277	Nelarabine CAS:121032-29-9	Nelarabine(Arranon,506U78)is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15μM in tumor cells.	price>
R-C-2279	Raltitrexed CAS:112887-68-0	Raltitrexed(Tomudex)is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.	price>
R-C-2280	Clofarabine CAS:123318-82-1	Clofarabine is a second generation purine nucleoside analog with antineoplastic activity.Clofarabine is phosphorylated intracellularly to the cytotoxic active 5-triphosphate metabolite,which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase,resulting in inhibition of DNA repair and synthesis of DNA and RNA.This nucleoside analog also disrupts mitochondrial function and membrane integrity,resulting in the release of pre-apoptotic factors,including cytochrome C and apoptotic-inducing factor,which activate apoptosis.	price>
R-C-2496	Uramustine CAS：66-75-1	Uramustine(INN）uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents.It is used in lymphatic malignancies such as non-Hodgkin is lymphoma.It works by damaging DNA,primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division.The DNA damage leads to apoptosis of the affected cells.Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.	price>
R-C-2551	Epirubicin hydrochloride CAS:56390-09-1	Epirubicin is a cell-permeable anthracycline antitumor antibiotic.It is a stereoisomer(4-epi-isomer)of doxorubicin that exhibits reduced cardiotoxicity.It is used to inhibit topoisomerase II and DNA helicase activity.	price>
R-C-2571	Carmoisine CAS:154-93-8	Carmustine(bis-chloroethylnitrosourea,BCNU,BiCNU)is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.	price>
R-C-2585	Melphalan CAS:148-82-3	Melphalan is a cytotoxic drug used to treat multiple myeloma.Phenylamine derivative of mechorethamine.	price>
R-C-2595	Betulinic acid CAS:472-15-1	Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba,the common white birch)with antiinflammatory,anti-HIV and antineoplastic activities.Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species,and opening of mitochondrial permeability transition pores,resulting in the release of mitochondrial apogenic factors, activation of caspases,and DNA fragmentation.	price>
R-C-2652	CAY10603 CAS:1045792-66-2	CAY10603(BML-281)is a potent and selective HDAC6 inhibitor,with an IC50 of 2 pM;CAY10603(BML-281)also inhibits HDAC1,HDAC2,HDAC3,HDAC8,HDAC10,with IC50s of 271,252,0.42,6851,90.7nM.	price>

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