Product apis-tgf-beta-smad

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Catalog	name	Description	price
R-R-2635	Hydrochlorothiazid-d2 CAS No.1219798-89-6	Hydrochlorothiazid-d2/CAS No.1219798-89-6 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.	price>
R-R-2636	Hydrochlorothiazid-13C,d2 CAS No.1190006-03-1	Hydrochlorothiazid-13C,d2/CAS No.1190006-03-1 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.	price>
R-R-2637	Hydrochlorothiazide-13C6 CAS No.1261396-79-5	Hydrochlorothiazide-13C6/CAS No.1261396-79-5 is the 13C labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.	price>
R-R-2638	10,11-Dehydrocurvularin CAS No.21178-57-4	10,11-Dehydrocurvularin/CAS No.21178-57-4 is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.	price>
R-C-1026	kartogenin CAS No. 4727-31-5	Kartogenin(KGN)is an inducer of differentiation of human mesenchymal stem cells into chondrocytes,with an EC50 of 100 nM. Kartogenin binds filamin A,disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ),and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program.Kartogenin can be used for the research of osteoarthritis(OA).	price>
R-C-1109	ITD1 CAS:1099644-42-4	ITD 1 is an inhibitor of TGF-β(IC50=0.85 µM).It is selective for TGF-β in an SBE4/Smad reporter assay,providing 83% inhibition when used at a concentration of 2.5 µM,over activin A,which is inhibited by 51% when used at the same concentration.ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation.It stimulates differentiation of mouse embryonic stem cells (mESCs)into cardiomyocytes.	price>
R-C-1115	SD208 CAS：627536-09-8	SD-208 is a potent,orally active ATP-competitive transforming growth factor-β receptor 1(TGF-βRI)inhibitor(IC50=49 nM);displays>100-fold and>17-fold selectivity over TGF-βRII and other common kinases respectively.	price>
R-C-1189	ITD-1 CAS:1099644-42-4	ITD-1 is a selective inhibitor of TGF-β signaling (IC50=0.85μM);displays little or no inhibition of activin,Wnt or BMP signaling pathways.ITD-1 selectively enhanced the differentiation of uncommitted mesoderm to cardiomyocytes,but not to vascular smooth muscle and endothelial cells.ITD-1 is a highly selective TGF-β inhibitor and reveals an unexpected role for TGF-β signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors.	price>
R-C-1300	TAS-301 CAS:193620-69-8	TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery.TAS-103 inhibits smooth muscle cell migration and proliferation.TAS-103 inhibits intimal thickening after balloon injury to rat carotid arteries.TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor.TAS-103 inhibits calcium-dependent signal transduction and cytoskeletal reorganization.	price>
R-C-1547	LY317615 (Enzastaurin) CAS:170364-57-5	Enzastaurin(LY317615)is a potent and selective PKCβ inhibitor with an IC50 of 6 nM,showing 6- to 20-fold selectivity over PKCα,PKCγ and PKCε.	price>

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