ITD1 CAS:1099644-42-4

ITD 1 is an inhibitor of TGF-β(IC50=0.85 µM).It is selective for TGF-β in an SBE4/Smad reporter assay,providing 83% inhibition when used at a concentration of 2.5 µM,over activin A,which is inhibited by 51% when used at the same concentration.ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation.It stimulates differentiation of mouse embryonic stem cells (mESCs)into cardiomyocytes.

msds---ITD1