Catalog name Description price
R-C-440 LY2157299 Galunisertib(LY2157299)is selective TGF-receptor kinase inhibitor.Galunisertib was found to inhibit the growth in an in vitro clonogenic assay in 6.3%(5/79)of the examined PDX. price>
R-C-498 LY2109761 cas:700874-71-1 LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay,respectively;shown to negatively affect the phosphorylation of Smad2.LY2109761 blocks autophagy and induces apoptosis. price>
R-C-549 GW788388 CAS: 452342-67-5 GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay,also inhibits TGF-βtype II receptor and activin type II receptor activities,but does not inhibit BMP type II receptor. price>
R-C-559 LY364947 cas:396129-53-6 LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM,and exhibits 7-fold selectivity over TGFβR-II. price>
R-C-570 SB431542 cas:301836-41-9 SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4,ALK5,and ALK7. price>
R-C-639 SB505124 cas:694433-59-5 SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5),ALK4 and ALK7(IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). price>
R-C-713 SB525334 cas:356559-20-1 SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5,TGF-βRI)(IC50=14.3 nM).Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. price>
R-R-2612 Halofuginone CAS No.55837-20-2 Halofuginone (RU-19110)/CAS No.55837-20-2, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects. price>
R-R-2613 SRI-011381 hydrochloride CAS No.2070014-88-7 SRI-011381 hydrochloride/CAS No.2070014-88-7 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects. price>
R-R-2614 Trabedersen sodium Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen sodium can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon. price>