Product apis-tgf-beta-smad

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Catalog	name	Description	price
R-C-2635	Pirfenidone CAS:53179-13-8	Pirfenidone(AMR69)is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells.Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines.Pirfenidone also has anti-inflammatory activities.	price>
R-C-2636	A 77-01 CAS:607737-87-1	A 77-01 is a potent inhibitor of transforming growth factor(TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25nM.	price>
R-C-2637	Rottlerin CAS:82-08-6	Rottlerin is an angiogenesis inhibitor and an inhibitor of protein kinase Cdelta (PKCdelta)and calmodulin kinase III.Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells.Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells.	price>
R-C-2638	Bryostatin 1 CAS:83314-01-6	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system(CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07nM and 0.45nM,respectively.	price>
R-C-2639	ZIP CAS:863987-12-6	ZIP is a selective peptide inhibitor of PKMζ.ZIP injections can block the impairment in morphine conditioned place preference induced.	price>
R-C-2640	PPY A CAS:875634-01-8	PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases(IC50 values are 9 and 20nM,respectively).Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.	price>
R-C-2641	Bryostatin 2 CAS:87745-28-6	Bryostatin 2 is a protein kinase C(PKC)activator.	price>
R-C-2642	A 83-01 CAS: 909910-43-6	A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase,type I nodal receptor ALK4 and type I nodal receptor ALK7,with IC50s of 12nM,45nM and 7.5nM against the transcription induced by ALK5,ALK4 and ALK7,respectively.	price>
R-C-3014	SB525334 CAS：356559-20-1	SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.Only for scientific research, not for human body.	price>

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