Product apis-tgf-beta-smad

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Catalog	name	Description	price
R-C-1564	go6983 CAS：133053-19-7	Go 6983 is a pan-PKC inhibitor against for PKCα,PKCβ,PKCγ,PKCδand PKCζ with IC50 of 7 nM,7 nM,6nM,10 nM and 60 nM,respectively.	price>
R-C-1615	SIS3 HCL CAS：521984-48-5	SIS3 is a novel specific inhibitor of Smad3.It has effect on transforming growth factor-beta1-induced extracellular matrix expression.	price>
R-C-1660	GF109203X CAS：133052-90-1	Bisindolylmaleimide I(GF109203X,GO 6850)is a potent PKC inhibitor with IC50 of 20 nM,17 nM,16 nM,and 20 nM for PKCα,PKCβI,PKCβII,and PKCγ in cell-free assays,respectively,showing more than 3000-fold selectivity for PKC as compared to EGFR,PDGFR and insulin receptor.	price>
R-C-2252	Daphnoretin CAS： 2034-69-7	Daphnoretin(Dephnoretin,Thymelol),a biologically active compound isolated from Wikstroemia indica C.A.Mey.,is a protein kinase C(PKC)activator.Daphnoretin inhibits the proliferation,invasion,and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.	price>
R-C-1913	LY3200882 CAS： 1898283-02-7	LY 3200882 is a potent,highly selective inhibitor of TGF-β receptor type 1(TGFβRI).It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.	price>
R-C-3019	Staurosporine (AM-2282) CAS：62996-74-1	Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.Only for scientific research, not for human body.	price>
R-C-2059	LDN-193189 CAS:1062368-24-4	LDN-193189(DM3189)is a selective BMP signaling inhibitor, inhibits the ALK1,ALK2,ALK3 and ALK6 with IC50s of 0.8 nM,0.8nM,5.3nM and 16.7nM in the kinase assay,respectively.LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30nM in C2C12 cells,respectively,exhibits 200-fold selectivity for BMP versus TGF-β.For animal testing,the water-soluble S7507 LDN-193189 2HCl is recommended.	price>
R-C-2281	Go6976 CAS:136194-77-9	Go6976 is a potent PKC inhibitor with IC50 of 7.9nM,2.3nM,and 6.2nM for PKC(Rat brain),PKCα,and PKCβ1,respectively.Also a potent inhibitor of JAK2 and Flt3.	price>
R-C-2382	K02288 CAS：1431985-92-0	K02288 is a potent bone morphogenetic protei(BMP)type I receptor inhibitor with IC50s of 1.8,1.1,6.4nM for ALK1,ALK2 and ALK6,respectively.K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34nM.	price>
R-C-2482	Hypocrellin A CAS:77029-83-5	Hypocrellin A(HA)is a perylenequinone isolated from Shiraia bambusicola that shows antiviral,antimicrobial and anticancer activity through mediating multiple signaling pathways.Hypocrellin A also is a selective and potent inhibitor of PKC.	price>

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