Product apis-tgf-beta-smad

Home > products > apis> tgf-beta-smad

Catalog	name	Description	price
R-C-2611	SC-10 CAS:102649-79-6	SC-10 is a PKC activator.It acts by stimulating PKC mediated myosin light chain phosphorylation without activating MLC kinase.	price>
R-C-2612	ML347 CAS:1062368-49-3	ML347(DN193719)is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32nM; shows>300-fold selectivity for ALK2 vs.	price>
R-C-2613	SR-3677 CAS:1072959-67-1	SR-3677 is a novel,potent and highly selective inhibitor of Rho Kinase(ROCK-II) with the IC50 value of ~0.3nM in enzyme and cell based assays.	price>
R-C-2614	DMH-1 CAS:1206711-16-1	DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6,respectively.	price>
R-C-2616	Calphostin C CAS:121263-19-2	The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.The known calphostins include calphostin A,calphostin B,calphostin C,calphostin D,and calphostin I.The calphostins are inhibitors of protein kinase C(PKC).	price>
R-C-2617	PKC fragment (530-558)	Potent activator of protein kinase C(Ka~10 mM);corresponds to residues 530-558 of the catalytic domain of PKC.	price>
R-C-2618	Ro 31-8220 Mesylate CAS:138489-18-6	Ro 31-8220 is a PKC-inhibitor,which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA,IC50=1.35 x 10(-6)M)or diacylglycerols(OAG,diC8)by 95%.Ro-31-8220 showed the apoptotic effect on HL-60 cells,which was mediated by a well-characterized transduction process of apoptotic signals:i.e.,mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol.	price>
R-C-2620	Vactosertib (TEW-7197) CAS:1352608-82-2	Vactosertib(EW-7197)is a potent,orally active and ATP-competitive activin receptor-like kinase 5(ALK5)inhibitor with an IC50 of 12.9nM.Vactosertib also inhibits ALK2 and ALK4(IC50 of 17.3nM)at nanomolar concentrations.Vactosertib has potently antimetastatic activity and anticancer effect.	price>
R-C-2621	LDN-212854 CAS:1432597-26-6	LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors;possesses a bias towards ALK2(IC50=1.3nM)versus ALK1 and ALK3 compared to other inhibitors.	price>
R-C-2622	CGP 53353 CAS:145915-60-2	Selective inhibitor of PKCβII(IC50 values are 0.41 and 3.8μM for PKCβII and PKCβI respectively).Also inhibits prionogenic Sup35 fibrillization (IC50~ 3.4μM)and inhibits de novo Aβ42 assembly in vitro.	price>

...