Product apis-tgf-beta-smad

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Catalog	name	Description	price
R-R-2625	Trabedersen CAS No.925681-61-4	Trabedersen (AP 12009)/CAS No.925681-61-4 is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon.	price>
R-R-2626	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine CAS No.2347517-69-3	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine/CAS No.2347517-69-3 is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia.	price>
R-R-2627	Trimethylamine N-oxide-d9 CAS No.1161070-49-0	Trimethylamine N-oxide-d9/CAS No.1161070-49-0 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.	price>
R-R-2628	Isoviolanthin CAS No.40788-84-9	Isoviolanthin/CAS No.40788-84-9, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells.	price>
R-R-2629	ALK5-IN-34 CAS No.2785430-90-0	ALK5-IN-34/CAS No.2785430-90-0 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 can inhibit the activity of ALK5-IN-34 with an IC50 value of ≤10 nM. ALK5-IN-34 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer.	price>
R-R-2630	Butaprost CAS No.69685-22-9	Butaprost/CAS No.69685-22-9 is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling.	price>
R-R-2631	Pirfenidone-d5 CAS No.1020719-62-3	Pirfenidone-d5/CAS No.1020719-62-3 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities.	price>
R-R-2632	Mongersen CAS No.1443994-46-4	Mongersen (GED-0301)/CAS No.1443994-46-4 is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals.	price>
R-R-2633	Elezanumab CAS No.1791416-49-3	Elezanumab (ABT-555; AE12-1Y-QL)/CAS No.1791416-49-3 is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.	price>
R-R-2634	IDE 2 CAS No.1136466-93-7	IDE2/CAS No.1136466-93-7 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway.	price>

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