Product apis-tgf-beta-smad

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Catalog	name	Description	price
R-R-2615	SRI-011381 CAS No.1629138-41-5	SRI-011381/CAS No.1629138-41-5 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.	price>
R-R-2616	Halofuginone hydrobromide CAS No.64924-67-0	Halofuginone (RU-19110) hydrobromid/CAS No.64924-67-0, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.	price>
R-R-2617	Ponsegromab CAS No.2368950-15-4	Ponsegromab (PF 06946860)/CAS No.2368950-15-4 is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers.	price>
R-R-2618	EMT inhibitor-1 CAS No.1638526-21-2	EMT inhibitor-1/CAS No.1638526-21-2 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.	price>
R-R-2619	R-268712 CAS No.879487-87-3	R-268712/CAS No.879487-87-3 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.	price>
R-R-2620	Luspatercept CAS No.1373715-00-4	Luspatercept (ACE-536)/CAS No.1373715-00-4 is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.	price>
R-R-2621	Carotuximab CAS No.1268714-50-6	Carotuximab (TRC105)/CAS No.1268714-50-6 is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.	price>
R-R-2622	SIS3 free base CAS No.521985-36-4	SIS3 free base/CAS No.521985-36-4 is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.	price>
R-R-2623	Livmoniplimab CAS No.2412004-88-5	Livmoniplimab (ABBV-151; ARGX-115)/CAS No.2412004-88-5 is a potent, humanized monoclonal antibody against the LRRC32 (GARP)/TGFβ1 complex. Livmoniplimab blocks LRRC32-mediated latent TGFβ1 activation and release. Livmoniplimab has potential in cancer research as a single anticancer agent or in combination with an anti-PD-1 mAb to inhibit locally advanced or metastatic solid tumors (NCT03821935).	price>
R-R-2624	SJ000063181 CAS No.945189-68-4	SJ000063181/CAS No.945189-68-4 is a potent BMP signaling activator with an EC50 ≤1 µM. SJ000063181 can be used as chemical probes to interrogate BMP signaling due to it can penetrate zebrafish embryos.	price>

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