Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-658	Amuvatinib (MP-470) CAS :850879-09-3	Amuvatinib(MP470)is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit,PDGFRα,Flt3,c-Met and c-Ret.Amuvatinib(MP470)is also a DNA repair suppressor through suppression of DNA repair protein RAD51,thereby disrupting DNA damage repair. Antineoplastic activity.	price>
R-C-670	E7080(Lenvatinib) cas:417716-92-8	Lenvatinib(E7080)is an oral,multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3,FGFR1-4,PDGFR,KIT,and RET,shows potent antitumor activities.	price>
R-C-743	GSK1838705A CAS:1116235-97-2	GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L,respectively.	price>
R-C-761	SKLB1002 cas:1225451-84-2	SKLB1002 is a new potent VEGFR2 inhibitor,which could significantly inhibit HUVEC proliferation,migration,invasion,and tube formation.	price>
R-C-975	Vatalanib CAS 212141-54-3	Vatalanib,also called as PTK 787 or CGP 797870,is a small molecule that interacts reversibly and competitively at the ATP-binding site of the receptor tyrosine kinase domain to inhibit autophosphorylation.It targets all known VEGFR tyrosine kinases.	price>
R-C-980	TUS-68(SU6668,Orantinib)	Orantinib(TSU-68,SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay,but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation,little activity against IGF-1R,Met,Src,Lck,Zap70,Abl and CDK2;does not inhibit EGFR.	price>
R-C-989	EMD-1214063 cas:1100598-32-0	EMD-1214063 is an inhibitor of met tyrosine kinase with IC50 of 4 nm.The selectivity of emd-1214063 to c-met is 200 times higher than that to irak4, TrkA,Axl,irak1 and mer.It has potential antitumor activity.It binds to met tyrosine kinase and destroys met signal transduction pathway,which may induce apoptosis in tumor cells overexpressing met tyrosine kinase.	price>
R-C-999	INCB28060 cas:1029712-80-8	INCB28060,a novel inhibitor of c-MET kinase.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases.This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.	price>
R-C-1001	TAE684 (NVP-TAE684) cas:761439-42-3	TAE684(NVP-TAE684)is a selective inhibitor of ALK with IC50 value of 3 nM .TAE684(NVP-TAE684)is a potent ALK inhibitor and has a different selectivity with the reported ALK inhibitor crizotinib.When tested with ALCL cell lines—Karpas-299 and SU-DHL-1 expressing NPM-ALK,TAE684(NVP-TAE684)inhibited cell proliferation and cell apoptosis in dose-dependent manner.In lung cancer cell lines harboring wild-type,H694R or E1384K mutant ALKs,TAE684 showed effective inhibition on cell proliferation and phospho-Y1604 ALK expression of H694R or E1384K mutant ALK,but also to a degree higher than that of wild-type ALK.	price>
R-C-1002	NVP-AEW541 cas:474589-16-8	NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R(IC50=0.086 uM)and prevents IGF-1-mediated survival and proliferation of MCF-7 cells(IC50=0.16 and 1.64 uM,respectively).	price>

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