PF-04217903 cas:956905-27-4
PF-04217903
Catalog # | Pkg Size | Price(USD) | Quantity | Buy this product |
---|---|---|---|---|
R-C-1006 | 10mg | 115.00 | + Add to cart |
|
R-C-1006 | 50mg | 350.00 | + Add to cart |
|
R-C-1006 | 100mg | 620.00 | + Add to cart |
|
|
Product description
PF-04217903(PF-4217903)is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to 142 nM.PF-04217903(PF-4217903) demonstrated>1000 fold selectivity for c-Met compared with>150 kinases, making it one of the most selective c-Met inhibitors described to date.PF-04217903(PF-4217903)inhibited tumor cell proliferation,survival,migration/invasion in MET amplified cell lines in vitro,and demonstrated marked antitumor activity in tumor models harboring either MET gene amplification or a HGF/c-Met autocrine loop at well-tolerated dose levels in vivo.
Appearance | N/A |
---|---|
Molecular Weight | N/A |
purity | >95% |
PDI by GPC | <1.5 |
Solubility | N/A |
Storage | -20℃, protected from light and moisture |
Transportation | 4-25℃ temperature for up to 2 weeks |
Stability | 1 year |
Document
Related Product