Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-507	Mastinib cas:790299-79-5	Masitinib(AB1010)is a potent,orally bioavailable,and selective inhibitor of c-Kit(IC50=200 nM for human recombinant c-Kit).It also inhibits PDGFRα/β(IC50s=540/800 nM),Lyn(IC50= 510 nM for LynB),Lck,and,to a lesser extent,FGFR3 and FAK.Masitinib (AB1010) has anti-proliferative,pro-apoptotic activity and low toxicity.	price>
R-C-515	TAK285 CAS：871026-44-7	TAK-285 is a potent,selective,ATP-competitive and orally active HER2 and EGFR(HER1)inhibitor with IC50 of 17 nM and 23 nM,respectively.TAK-285 is >10-fold selectivity for HER1/2 than HER4,and less potent to MEK1/5,c-Met,Aurora B,Lck,CSK etc.TAK-285 has effective antitumor activity.TAK-285 can cross the blood-brain barrier(BBB).	price>
R-C-521	LY2811376 cas:1194044-20-6	LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM,that act to decrease Aβ secretion with EC50 of 300 nM,demonstrated to have 10-fold selectivity towards BACE1 over BACE2,and more than 50-fold inhibition over other aspartic proteases including cathepsin D,pepsin, or renin.	price>
R-C-523	PF-02341066 cas:877399-52-5	Crizotinib(PF-02341066)is an orally bioavailable,ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively.Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays,respectively.Crizotinib is also a ROS1 inhibitor.Crizotinib has effective tumor growth inhibition.	price>
R-C-530	R406 cas:841290-80-0	R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM,potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM,measured at an ATP concentration corresponding to its Km value.R406 reduces immune complex-mediated inflammation.R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).	price>
R-C-546	AG-490 CAS: 134036-52-5	AG-490(Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1μM).It is 135-fold more selective for EGFR than ErbB2,also inhibits JAK2 with no effect to Lyn,Lck, Syk,Btk,and Src.	price>
R-C-552	KU14R CAS:189224-48-4	KU14R is a new I(3)-R antagonist,which selectively blocks the insulin secretory response to imidazolines.	price>
R-C-561	ZM323881 cas:324077-30-7	ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC50=8 nM) and VEGF-R2 tyrosine phosphorylation(IC50Vascular endothelial growth factor(VEGF) increases vascular permeability and angiogenesis in many pathological conditions, such as cancer,arthritis,and diabetes.VEGF activates VEGF-Receptor 1(VEGF-R1)and VEGF-Receptor 2(VEGF-R2)that autophosphorylate to initiate a signaling cascade resulting in angiogenesis and increased microvascular permeability.ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase.	price>
R-C-562	ZM306416 cas:690206-97-4	ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt,respectively.ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.	price>
R-C-566	ASP3026 cas:1097917-15-1	ASP3026 is a potent,selective and orally active inhibitor of anaplastic lymphoma kinase(ALK).ASP3026 induces apoptosis of tumor cells.ASP3026 can be used for the research of non-small cell lung cancer (NSCLC).	price>

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