Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-586	NVP-BHG712 cas:940310-85-0	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf,c-Src and c-Abl with IC50 of 0.395 μM,1.266 μM and 1.667 μM,respectively.	price>
R-C-589	AZD8931 cas:848942-61-0	Sapitinib(AZD8931)is a reversible,ATP competitive inhibitor of EGFR,ErbB2 and ErbB3 with IC50 of 4 nM,3 nM and 4 nM in cell-free assays,more potent than Gefitinib or Lapatinib against NSCLC cell,100-fold more selective for the ErbB family than MNK1 and Flt.	price>
R-C-597	XL647 cas:781613-23-8	XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization,including EGFR,HER2,ERBB2,VEGFR and EphB4.	price>
R-C-608	SU11274 cas:658084-23-2	SU11274(PKI-SU11274)is a selective Met(c-Met)inhibitor with IC50 of 10 nM in cell-free assays,no effects on PGDFRβ,EGFR or Tie2.SU11274 induces autophagy,apoptosis and cell cycle arrest.	price>
R-C-611	LDK378 cas:1032900-25-6	LDK378 is a highly selective,orally bioavailable and ATP-competitive small molecule inhibitor of ALK(Anaplastic Lymphoma Kinase),a receptor tyrosine kinase considered to be an important lung cancer drug target.	price>
R-C-634	CP868596 cas:670220-88-9	Crenolanib(CP-868596,ARO 002)is a potent and selective inhibitor of PDGFRα/βwith Kd of 2.1 nM/3.2 nM in CHO cells,also potently inhibits FLT3,sensitive to D842V mutation not V561D mutation,>100-fold more selective for PDGFR than c-Kit,VEGFR-2,TIE-2,FGFR-2,EGFR,erbB2,and Src.Crenolanib helps to induce mitophagy.	price>
R-C-642	PD153035HCl CAS No. 183322-45-4	PD153035 HCl(SU-5271 HCl,AG1517 HCl,ZM 252868 HCl) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM in cell-free assays; little effect noted against PGDFR,FGFR,CSF-1,InsR and Src.	price>
R-C-650	KI8751 cas:228559-41-9	Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.	price>
R-C-651	Rociletinib (CO-1686) cas:1374640-70-6	Rociletinib(CO-1686,AVL-301)is an irreversible,mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays,respectively.	price>
R-C-655	SKLB610 cas:1125780-41-7	SKLB610 is a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.	price>

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