Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1111	Sunitinib (SU 11248) CAS：557795-19-4	Sunitinib(SU 11248)is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ,respectively.Sunitinib, an ATP-competitive inhibitor,effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.	price>
R-C-1113	AC710 CAS:1351522-04-7	AC710 is a potent,orally active,and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity.	price>
R-C-1132	BIBX1382 CAS:196612-93-8	BIBX 1382 is a cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible,ATP-competitive,and highly selective inhibitor of EGFR.	price>
R-C-1136	PF-562271 CAS ：717907-75-0	PF-562271 Besylate is the benzenesulfonate salt of PF-562271,which is a potent,ATP-competitive,reversible inhibitor of FAK with IC50 of 1.5 nM,~10-fold less potent for Pyk2 than FAK and>100-fold selectivity against other protein kinases,except for some CDKs.	price>
R-C-1141	CL-387785 (EKI-785) CAS :194423-06-8	CL-387785,also known as EKI-785,is a n irreversible inhibitor of EGF-receptor (EGFR)kinase activity in vivo(IC50=250-490 pM).CL-387785 covalently bound to EGF-R.It also specifically inhibited kinase activity of the protein(IC50 =370+/-120 pM),blocked EGF-stimulated autophosphorylation of the receptor in cells(ic50 approximately 5 nM),inhibited cell proliferation(IC50=31-125nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2,and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice(when given orally at 80 mg/kg/day for 10 days,daily).	price>
R-C-1142	GW2580 CAS:870483-87-7	GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM.GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling.	price>
R-C-1153	SU6656 cas:330161-87-0	SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase.SU6656 modulates CTGF(connective tissue growth factor)expression in an ERK-dependent manner.SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth,invasion and angiogenesis in vivo.	price>
R-C-1158	Pexidartinib (PLX-3397) CAS:1029044-16-3	Pexidartinib(PLX-3397)is a potent, orally active,selective, and ATP-competitive colony stimulating factor 1 receptor(CSF1R or M-CSFR)and c-Kit inhibitor,with IC50s of 20 and 10 nM respectively.Pexidartinib(PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases.Pexidartinib(PLX-3397)induces cell apoptosis and has anti-tumor activity.	price>
R-C-1171	LY2874455 CAS：1254473-64-7	LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM,2.6 nM,6.4 nM,and 6 nM for FGFR1,FGFR2,FGFR3,and FGFR4,respectively,and also inhibits VEGFR2 activity with IC50 of 7 nM.	price>
R-C-1173	TP-0903 CAS：1341200-45-0	TP-0903 is a potent and selective AXL Inhibitor with IC50 of 27 nM.TP-0903 is highly effective in inducing apoptosis.	price>

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