Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1211	SU-5614 CAS:1055412-47-9	SU5614 is a potent and selective FLT3 inhibitor.SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand(FL)in FL-dependent cells.	price>
R-C-1218	Altiratinib CAS:1345847-93-9	Altiratinib,also known as DCC-270,DP-5164,is an oral,selective and highly potent inhibitor of MET,TIE2,VEGFR2 and TRK kinases with potential anticancer activity.DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling,cell growth and migration as compared with a HGF antagonist in vitro. Importantly,DCC-2701 is anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF.	price>
R-C-1274	BMS754807 CAS：1001350-96-4	BMS-754807 is an efficacious,orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.	price>
R-C-1281	(Linsitinib)OSI-906 CAS：867160-71-2	Linsitinib(OSI-906)is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays;modestly potent to InsR with IC50 of 75 nM,and no activity towards Abl,ALK,BTK,EGFR,FGFR1/2,PKA etc.	price>
R-C-1282	AZD3759 CAS:1626387-80-1	AZD3759 is a potent,oral active,CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM,0.2nM,and 0.2nM for EGFR(WT),EGFR(L858R),and EGFR(exon 19Del),respectively.	price>
R-C-1289	Entospletinib (GS-9973) CAS：1229208-44-9	Entospletinib,also known as GS-9973,is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.In Phase II clinical trials,Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.	price>
R-C-1303	CYC-116 CAS：693228-63-6	Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2(VEGFR2),resulting in disruption of the cell cycle,rapid cell death, and the inhibition of angiogenesis.	price>
R-C-1305	AV-412 CAS：451493-31-5	AV-412,also known as MP-412,is a second-generation,orally bioavailable dual kinase inhibitor with potential antineoplastic activity.EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2),which may result in the inhibition of tumor growth and angiogenesis,and tumor regression in EGFR/HER2-expressing tumors.This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors.EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.	price>
R-C-1314	AMG337 CAS:1173699-31-4	AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor.AMG 337 inhibits MET kinase activity with an IC50 of<5nM in enzymatic assays.	price>
R-C-1359	PD168393 CAS No. 194423-15-9	PD168393 is a potent,selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2.PD168393 irreversiblely inactivates EGF receptor(IC50=0.7 nM)and is inactive against insulin receptor,PDGFR,FGFR and PKC.	price>

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