Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1504	azd2932 CAS:883986-34-3	AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR.AZD-2932 has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes,respectively.It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases.	price>
R-C-1536	UNC2025 CAS:1429881-91-3	UNC2025 is a potent,ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively.UNC2025 is>45-fold selectivity for MERTK relative to Axl(IC50=122 nM;Ki=13.3 nM).UNC2025 exhibits an excellent PK properties,and can be used for the investigation of acute leukemia.	price>
R-C-1571	Fenebrutinib (GDC-0853) CAS：1434048-34-6	Fenebrutinib(GDC-0853)is a potent,selective, orally available,and noncovalent bruton is tyrosine kinase(Btk)inhibitor with Kis of 0.91 nM,1.6,1.3,12.6,and 3.4 nM for WT Btk,and the C481S,C481R,T474I,T474M mutants.Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research.	price>
R-C-1607	FGFR4-IN-1 CAS：1708971-72-5	FGFR4-IN-1 is a potent and selective FGFR4 inhibitor.FGFR4 may be a novel therapeutic target for gastric cancer.	price>
R-C-1608	DBPR-114 CAS：2443767-35-7	BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA,respectively,acts as a preclinical development candidate for anti-cancer therapy.	price>
R-C-1618	BAW2881 CAS： 861875-60-7	NVP-BAW2881(BAW2881)is a potent and selective VEGFR2 inhibitor with an IC50 of 4nM.	price>
R-C-1669	AG-1478 (Tyrphostin AG-1478) CAS：153436-53-4	AG-1478(Tyrphostin AG-1478,NSC 693255)is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays,almost no activity on HER2-Neu,PDGFR, Trk,Bcr-Abl and InsR.AG-1478(Tyrphostin AG-1478)inhibits encephalomyocarditis virus(EMCV)and hepatitis c virus(HCV)by targeting phosphatidylinositol 4-kinase IIIα(PI4KA).	price>
R-C-1683	LY2801653 CAS：1206799-15-6	Merestinib(LY2801653)is a type-II ATP competitive,slow-off inhibitor of Met(c-Met)tyrosine kinase with a dissociation constant(Ki)of 2 nM, a pharmacodynamic residence time(Koff)of 0.00132 min(-1)and t1/2 of 525 min.Merestinib (LY2801653) also inhibits MST1R,AXL,ROS1,MKNK1/2, FLT3,MERTK,DDR1 and DDR2 with IC50 of 11 nM,2nM,23nM,7nM,7nM,10 nM,0.1nM and 7nM,respectively.	price>
R-C-1689	ONO-4059 analogue CAS：1351635-67-0	ONO-4059 analog is the analog of ONO-4059,ONO-4059 is a highly potent and selective Btk inhibitor.	price>
R-C-1707	XMD8-87 CAS:1234480-46-6	XMD8-87 is a TNK2 inhibitor.XMD8-87 showed activity in the inhibition of TNK2 phosphorylation.XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.	price>

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