Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1717	DDR1-IN-1 CAS:1449685-96-4	DDR1-IN-1 is a potent and selective discoidin domain receptor 1(DDR1)receptor tyrosine kinase inhibitor with IC50 of 105 nM,about 3-fold selectivity over DDR2.	price>
R-C-1720	AZD0156 CAS:1821428-35-6	AZD0156 is a potent and selective inhibitors of ATM kinase,with potential chemo-/radio-snsitizing and antineoplastic activities.AZD0156 prevents DNA damage checkpoint activation,disrupts DNA damage repair,induces tumor cell apoptosis,and leads to cell death of ATM-overexpressing tumor cells.	price>
R-C-1721	ISCK03 CAS:945526-43-2	ISCK03(N-(4-imidazol-1-yl phenyl)sulfonamide)is a cell-permeable inhibitor of stem-cell factor(SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.	price>
R-C-1730	FGF-401 CAS: 1708971-55-4	Roblitinib(FGF401)is an FGFR4-selective inhibitor with an IC50 of 1.1nM.It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.	price>
R-C-1741	Avapritinib (BLU-285) CAS:1703793-34-3	Avapritinib(BLU-285)is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro(IC50=0.5nM)and PDGFRα D842V autophosphorylation in the cellular setting (IC50=30 nM);also a potent inhibitor of the analogous Kit(c-Kit)mutation,D816V in Kit(c-Kit)Exon 17(IC50=0.5nM).	price>
R-C-1768	Rogaratinib (BAY1163877) CAS:1443530-05-9	Rogaratinib(BAY1163877)is a potent and selective fibroblast growth factor receptor(FGFR)inhibitor.	price>
R-C-1778	A 419259 (trihydrochloride) CAS: 364042-47-7	A 419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor,designed to enhance selectivity towards the Src family with IC50 of 9 nM,<3 nM and<3nM for Src,Lck and Lyn,respectively.	price>
R-C-1802	AG 555 CAS：133550-34-2	AG 555(Tyrphostin AG 555),a potent antiretroviral drug,is a potent and selective inhibitor of EGFR and blocks Cdk2 activation.	price>
R-C-1812	SGX-523 CAS:1022150-57-7	SGX-523 is an orally bioavailable small molecule,specifically binds to c-Met protein,or HGFR,preventing binding of HGF and disrupting the MET signaling pathway.	price>
R-C-1841	Belizatinib (TSR011) CAS：1357920-84-3	Belizatinib is an oral,dual,potent inhibitor of ALK and TRKA,TRKB,and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.	price>

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