Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1708	XMD16-5 CAS:1345098-78-3	XMD16-5 is a tyrosine kinase nonreceptor 2(TNK2)inhibitor.TNK2 mutations have been found in renal cancer cells and also in lung, ovarian and gastric cancers. TNK2 genomic amplification has been associated with late stage or metastatic lung and prostate cancers.Overexpression of TNK2 promoted metastasis in a mouse model of breast cancer.	price>
R-C-1717	DDR1-IN-1 CAS:1449685-96-4	DDR1-IN-1 is a potent and selective discoidin domain receptor 1(DDR1)receptor tyrosine kinase inhibitor with IC50 of 105 nM,about 3-fold selectivity over DDR2.	price>
R-C-1720	AZD0156 CAS:1821428-35-6	AZD0156 is a potent and selective inhibitors of ATM kinase,with potential chemo-/radio-snsitizing and antineoplastic activities.AZD0156 prevents DNA damage checkpoint activation,disrupts DNA damage repair,induces tumor cell apoptosis,and leads to cell death of ATM-overexpressing tumor cells.	price>
R-C-1721	ISCK03 CAS:945526-43-2	ISCK03(N-(4-imidazol-1-yl phenyl)sulfonamide)is a cell-permeable inhibitor of stem-cell factor(SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.	price>
R-C-1730	FGF-401 CAS: 1708971-55-4	Roblitinib(FGF401)is an FGFR4-selective inhibitor with an IC50 of 1.1nM.It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.	price>
R-C-1741	Avapritinib (BLU-285) CAS:1703793-34-3	Avapritinib(BLU-285)is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro(IC50=0.5nM)and PDGFRα D842V autophosphorylation in the cellular setting (IC50=30 nM);also a potent inhibitor of the analogous Kit(c-Kit)mutation,D816V in Kit(c-Kit)Exon 17(IC50=0.5nM).	price>
R-C-1768	Rogaratinib (BAY1163877) CAS:1443530-05-9	Rogaratinib(BAY1163877)is a potent and selective fibroblast growth factor receptor(FGFR)inhibitor.	price>
R-C-1778	A 419259 (trihydrochloride) CAS: 364042-47-7	A 419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor,designed to enhance selectivity towards the Src family with IC50 of 9 nM,<3 nM and<3nM for Src,Lck and Lyn,respectively.	price>
R-C-1802	AG 555 CAS：133550-34-2	AG 555(Tyrphostin AG 555),a potent antiretroviral drug,is a potent and selective inhibitor of EGFR and blocks Cdk2 activation.	price>
R-C-1812	SGX-523 CAS:1022150-57-7	SGX-523 is an orally bioavailable small molecule,specifically binds to c-Met protein,or HGFR,preventing binding of HGF and disrupting the MET signaling pathway.	price>

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